(S)-3-(1,1-difluoro-2-oxo-2-phenylethyl)-3-hydroxy-1-methylindolin-2-one

Base Information

Chemical Name:(S)-3-(1,1-difluoro-2-oxo-2-phenylethyl)-3-hydroxy-1-methylindolin-2-one
CAS No.:1357155-43-1
Molecular Formula:C₁₇H₁₃F₂NO₃
Molecular Weight:317.292
Hs Code.:

Synonyms:(S)-3-(1,1-difluoro-2-oxo-2-phenylethyl)-3-hydroxy-1-methylindolin-2-one

Suppliers and Price of (S)-3-(1,1-difluoro-2-oxo-2-phenylethyl)-3-hydroxy-1-methylindolin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-3-(1,1-difluoro-2-oxo-2-phenylethyl)-3-hydroxy-1-methylindolin-2-one

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Technology Process of (S)-3-(1,1-difluoro-2-oxo-2-phenylethyl)-3-hydroxy-1-methylindolin-2-one

There total 7 articles about (S)-3-(1,1-difluoro-2-oxo-2-phenylethyl)-3-hydroxy-1-methylindolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 2058-74-4
1-methyl-1H-indole-2,3-dione

: 86340-78-5
2,2-difluoro-1-phenyl-1-trimethylsiloxyethene

: 1357155-43-1
(S)-3-(1,1-difluoro-2-oxo-2-phenylethyl)-3-hydroxy-1-methylindolin-2-one

Guidance literature:: 1-methyl-1H-indole-2,3-dione; With C₂₉H₃₀F₆N₄O₂; In tetrahydrofuran; at 0 - 20 ℃;

2,2-difluoro-1-phenyl-1-trimethylsiloxyethene; In tetrahydrofuran; at 0 ℃; for 72h; optical yield given as %ee; enantioselective reaction;
DOI:10.1039/c2cc17140f

Reference yield: 85.0%

: 2058-74-4
1-methyl-1H-indole-2,3-dione

: 2,2-difluoro-3-oxo-3-phenylpropanoic acid

: 1357155-43-1
(S)-3-(1,1-difluoro-2-oxo-2-phenylethyl)-3-hydroxy-1-methylindolin-2-one

Guidance literature:: With 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)urea; In tetrahydrofuran; at 20 ℃; for 96h; enantioselective reaction;
DOI:10.1002/adsc.201800831

Reference yield:

: 2058-74-4
1-methyl-1H-indole-2,3-dione

: 86340-78-5
2,2-difluoro-1-phenyl-1-trimethylsiloxyethene

: C₁₇H₁₃F₂NO₃

: 1357155-43-1
(S)-3-(1,1-difluoro-2-oxo-2-phenylethyl)-3-hydroxy-1-methylindolin-2-one

Guidance literature:: With N-[3,5-bis(trifluoromethyl)phenyl]-N'-[(9R)-6'-methoxycinchonan-9-yl]thiourea; In dichloromethane; at 0 ℃; for 3h; optical yield given as %ee;
DOI:10.1039/c2cc17140f