allyl 2-(4-benzyloxy-3-methoxyphenyl)-2-phenylacetate

Base Information

• Chemical Name: allyl 2-(4-benzyloxy-3-methoxyphenyl)-2-phenylacetate
• CAS No.: 180333-56-6
• Molecular Formula: C₂₅H₂₄O₄
• Molecular Weight: 388.463
• Mol file: 180333-56-6.mol

Synonyms:allyl 2-(4-benzyloxy-3-methoxyphenyl)-2-phenylacetate

Chemical Property of allyl 2-(4-benzyloxy-3-methoxyphenyl)-2-phenylacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of allyl 2-(4-benzyloxy-3-methoxyphenyl)-2-phenylacetate

There total 8 articles about allyl 2-(4-benzyloxy-3-methoxyphenyl)-2-phenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(benzyloxy)-3-methoxybenzonitrile (52805-34-2) → allyl 2-(4-benzyloxy-3-methoxyphenyl)-2-phenylacetate (180333-56-6)

Guidance literature:

Multi-step reaction with 7 steps

1: benzene / 1.) RT, 50 min, 2.) 70 deg C, 7 h

2: conc. aq. HCl / benzene; methanol; tetrahydrofuran / 7 h / Heating

3: 90 percent / tert-BuOK / dimethylsulfoxide / 18 h / Ambient temperature

4: 93.2 percent / BF₃*Et₂O / diethyl ether / 0.5 h / Ambient temperature

5: NaClO₂, 26percent aq. NaH₂PO₄, 2-methyl-2-butene / 2-methyl-propan-2-ol / 3 h / Ambient temperature

6: SOCl₂, DMF / CH₂Cl₂ / 1.) RT, overnight, 2.) reflux, 3.5 h

7: CH₂Cl₂ / 3 h / Ambient temperature

With hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; thionyl chloride; 2-methyl-but-2-ene; boron trifluoride diethyl etherate; potassium tert-butylate; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide; tert-butyl alcohol; benzene;

DOI:10.1248/cpb.44.1188

Reference yield:

phenylmagnesium chloride (100-59-4) → allyl 2-(4-benzyloxy-3-methoxyphenyl)-2-phenylacetate (180333-56-6)

Guidance literature:

Multi-step reaction with 7 steps

1: benzene / 1.) RT, 50 min, 2.) 70 deg C, 7 h

2: conc. aq. HCl / benzene; methanol; tetrahydrofuran / 7 h / Heating

3: 90 percent / tert-BuOK / dimethylsulfoxide / 18 h / Ambient temperature

4: 93.2 percent / BF₃*Et₂O / diethyl ether / 0.5 h / Ambient temperature

5: NaClO₂, 26percent aq. NaH₂PO₄, 2-methyl-2-butene / 2-methyl-propan-2-ol / 3 h / Ambient temperature

6: SOCl₂, DMF / CH₂Cl₂ / 1.) RT, overnight, 2.) reflux, 3.5 h

7: CH₂Cl₂ / 3 h / Ambient temperature

With hydrogenchloride; sodium chlorite; sodium dihydrogenphosphate; thionyl chloride; 2-methyl-but-2-ene; boron trifluoride diethyl etherate; potassium tert-butylate; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide; tert-butyl alcohol; benzene;

DOI:10.1248/cpb.44.1188

Reference yield:

<3-methoxy-4-(phenylmethoxy)phenyl>phenylmethane (96306-54-6) → allyl 2-(4-benzyloxy-3-methoxyphenyl)-2-phenylacetate (180333-56-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 90 percent / tert-BuOK / dimethylsulfoxide / 18 h / Ambient temperature

2: 93.2 percent / BF₃*Et₂O / diethyl ether / 0.5 h / Ambient temperature

3: NaClO₂, 26percent aq. NaH₂PO₄, 2-methyl-2-butene / 2-methyl-propan-2-ol / 3 h / Ambient temperature

4: SOCl₂, DMF / CH₂Cl₂ / 1.) RT, overnight, 2.) reflux, 3.5 h

5: CH₂Cl₂ / 3 h / Ambient temperature

With sodium chlorite; sodium dihydrogenphosphate; thionyl chloride; 2-methyl-but-2-ene; boron trifluoride diethyl etherate; potassium tert-butylate; N,N-dimethyl-formamide; In diethyl ether; dichloromethane; dimethyl sulfoxide; tert-butyl alcohol;

DOI:10.1248/cpb.44.1188

upstream raw materials:

allyl alcohol

(4-Benzyloxy-3-methoxy-phenyl)-phenyl-acetyl chloride

4-(benzyloxy)-3-methoxybenzonitrile

phenylmagnesium chloride

Downstream raw materials:

2-(4-benzyloxy-3-methoxyphenyl)-2-phenyl-4-pentenoic acid