(R)-3-phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propanenitrile

Base Information

Chemical Name:(R)-3-phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propanenitrile
CAS No.:1408253-41-7
Molecular Formula:C₁₅H₂₀BNO₂
Molecular Weight:257.14
Hs Code.:

Synonyms:(R)-3-phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propanenitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-3-phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propanenitrile

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Technology Process of (R)-3-phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propanenitrile

There total 3 articles about (R)-3-phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 4360-47-8
cinnamonitrile

: 73183-34-3
bis(pinacol)diborane

: 1408253-41-7
(R)-3-phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propanenitrile

Guidance literature:: With copper(l) chloride; sodium t-butanolate; In tetrahydrofuran; methanol; at 20 ℃; Inert atmosphere; Schlenk technique;
DOI:10.1021/jacs.6b03963

Reference yield:

: 4360-47-8
cinnamonitrile

: 73183-34-3
bis(pinacol)diborane

: 1408253-41-7
(R)-3-phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propanenitrile

: 1006696-26-9
(S)-3-phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propanenitrile

Guidance literature:: With methanol; copper(I) bromide dimethylsulfide complex; (S)-5-isobutyl-2-mesityl-1-phenyl-5,6-dihydro-2H-imidazo[5,1-a]isoquinolin-4-ium chloride; potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 12h; enantioselective reaction; Inert atmosphere;
DOI:10.1039/c0cc02211j

Reference yield:

: 1885-38-7
cinnamic nitrile

: 73183-34-3
bis(pinacol)diborane

: 1408253-41-7
(R)-3-phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propanenitrile

: 1006696-26-9
(S)-3-phenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propanenitrile

Guidance literature:: With (R)-(-)-1-[(S)-2-(diphenylphosphanyl)ferrocenyl]ethyldicycylohexylphosphane; copper(l) chloride; sodium t-butanolate; In tetrahydrofuran; methanol; Title compound not separated from byproducts.;
DOI:10.1002/anie.200703699