(+)-methyl (2E,6R)-6-({[(phenylmethyl)oxy]carbonyl}amino)-8-[(triphenylmethyl)oxy]oct-2-enoate

Base Information

Chemical Name:(+)-methyl (2E,6R)-6-({[(phenylmethyl)oxy]carbonyl}amino)-8-[(triphenylmethyl)oxy]oct-2-enoate
CAS No.:1315128-44-9
Molecular Formula:C₃₆H₃₇NO₅
Molecular Weight:563.693
Hs Code.:

Synonyms:(+)-methyl (2E,6R)-6-({[(phenylmethyl)oxy]carbonyl}amino)-8-[(triphenylmethyl)oxy]oct-2-enoate

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Chemical Property of (+)-methyl (2E,6R)-6-({[(phenylmethyl)oxy]carbonyl}amino)-8-[(triphenylmethyl)oxy]oct-2-enoate

Chemical Property:

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Technology Process of (+)-methyl (2E,6R)-6-({[(phenylmethyl)oxy]carbonyl}amino)-8-[(triphenylmethyl)oxy]oct-2-enoate

There total 5 articles about (+)-methyl (2E,6R)-6-({[(phenylmethyl)oxy]carbonyl}amino)-8-[(triphenylmethyl)oxy]oct-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6213-88-3
(E)-methyl 3-iodoacrylate

: C₄₀H₄₆BNO₃

: 1315128-44-9
(+)-methyl (2E,6R)-6-({[(phenylmethyl)oxy]carbonyl}amino)-8-[(triphenylmethyl)oxy]oct-2-enoate

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triphenyl-arsane; caesium carbonate; N,N-dimethyl-formamide; In tetrahydrofuran; water; at 20 ℃; Inert atmosphere;
DOI:10.1002/chem.201100649

Reference yield:

: C₂₆H₂₆O₄

: 1315128-44-9
(+)-methyl (2E,6R)-6-({[(phenylmethyl)oxy]carbonyl}amino)-8-[(triphenylmethyl)oxy]oct-2-enoate

Guidance literature:: Multi-step reaction with 4 steps

1: bis(1,5-cyclooctadiene)diiridium(I) dichloride; C₃₈H₃₄NO₄P; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine / tetrahydrofuran / 2.5 h / 50 °C / Inert atmosphere

2: potassium hydroxide / methanol / 2 h / 20 °C

3: tetrahydrofuran / 2 h / 50 °C / Inert atmosphere

4: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triphenyl-arsane; caesium carbonate; N,N-dimethyl-formamide / tetrahydrofuran; water / 20 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; bis(1,5-cyclooctadiene)diiridium(I) dichloride; triphenyl-arsane; C₃₈H₃₄NO₄P; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; caesium carbonate; N,N-dimethyl-formamide; potassium hydroxide; In tetrahydrofuran; methanol; water; 4: Suzuki-Miyaura coupling;
DOI:10.1002/chem.201100649

Reference yield:

: 1315179-34-0
(-)-phenylmethyl formyl((1S)-1-{2-[(triphenylmethyl)oxy]ethyl}prop-2-en-1-yl)carbamate

: 1315128-44-9
(+)-methyl (2E,6R)-6-({[(phenylmethyl)oxy]carbonyl}amino)-8-[(triphenylmethyl)oxy]oct-2-enoate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide / methanol / 2 h / 20 °C

2: tetrahydrofuran / 2 h / 50 °C / Inert atmosphere

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triphenyl-arsane; caesium carbonate; N,N-dimethyl-formamide / tetrahydrofuran; water / 20 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triphenyl-arsane; caesium carbonate; N,N-dimethyl-formamide; potassium hydroxide; In tetrahydrofuran; methanol; water; 3: Suzuki-Miyaura coupling;
DOI:10.1002/chem.201100649