(2R,4S,5S)-5-amino-N-butyl-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide

Base Information

Chemical Name:(2R,4S,5S)-5-amino-N-butyl-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide
CAS No.:131349-20-7
Molecular Formula:C₁₉H₃₈N₂O₂
Molecular Weight:326.523
Hs Code.:

Synonyms:(2R,4S,5S)-5-amino-N-butyl-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,4S,5S)-5-amino-N-butyl-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide

Chemical Property:

Purity/Quality:

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Technology Process of (2R,4S,5S)-5-amino-N-butyl-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide

There total 5 articles about (2R,4S,5S)-5-amino-N-butyl-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 128901-30-4
(4S,5S)-5-((R)-2-Butylcarbamoyl-3-methyl-butyl)-4-cyclohexylmethyl-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

: 131349-20-7
(2R,4S,5S)-5-amino-N-butyl-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide

Guidance literature:: With ammonium formate; palladium on activated charcoal; In ethanol; water; at 2 ℃;
DOI:10.1021/jm00171a006

Reference yield:

: 503-74-2
3-methylbutyric acid

: 131349-20-7
(2R,4S,5S)-5-amino-N-butyl-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LDA, 2.) HMPA / 1.) hexane, THF, 35 deg C, 30 min, 2.) 2 h

2: triethylamine, 1-hydroxybenzotriazole hydrate (HOBT), 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDC) / dimethylformamide

3: ammonium formate / 10percent Pd/C / H₂O; ethanol / 2 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; ammonium formate; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium diisopropyl amide; palladium on activated charcoal; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00171a006

Reference yield:

: 105852-50-4
3-(benzyloxycarbonyl)-4-(cyclohexylmethyl)-2,2-dimethyl-5-(iodomethyl)-(4S,5R)-1,3-oxazolidine

: 131349-20-7
(2R,4S,5S)-5-amino-N-butyl-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LDA, 2.) HMPA / 1.) hexane, THF, 35 deg C, 30 min, 2.) 2 h

2: triethylamine, 1-hydroxybenzotriazole hydrate (HOBT), 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDC) / dimethylformamide

3: ammonium formate / 10percent Pd/C / H₂O; ethanol / 2 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; ammonium formate; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium diisopropyl amide; palladium on activated charcoal; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00171a006