(4S,5S)-5-((R)-2-Butylcarbamoyl-3-methyl-butyl)-4-cyclohexylmethyl-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

Base Information

Chemical Name:(4S,5S)-5-((R)-2-Butylcarbamoyl-3-methyl-butyl)-4-cyclohexylmethyl-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester
CAS No.:128901-30-4
Molecular Formula:C₃₀H₄₈N₂O₄
Molecular Weight:500.722
Hs Code.:

Synonyms:(4S,5S)-5-((R)-2-Butylcarbamoyl-3-methyl-butyl)-4-cyclohexylmethyl-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

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Chemical Property of (4S,5S)-5-((R)-2-Butylcarbamoyl-3-methyl-butyl)-4-cyclohexylmethyl-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

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Technology Process of (4S,5S)-5-((R)-2-Butylcarbamoyl-3-methyl-butyl)-4-cyclohexylmethyl-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

There total 3 articles about (4S,5S)-5-((R)-2-Butylcarbamoyl-3-methyl-butyl)-4-cyclohexylmethyl-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 503-74-2
3-methylbutyric acid

: 128901-30-4
(4S,5S)-5-((R)-2-Butylcarbamoyl-3-methyl-butyl)-4-cyclohexylmethyl-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LDA, 2.) HMPA / 1.) hexane, THF, 35 deg C, 30 min, 2.) 2 h

2: triethylamine, 1-hydroxybenzotriazole hydrate (HOBT), 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDC) / dimethylformamide

With N,N,N,N,N,N-hexamethylphosphoric triamide; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium diisopropyl amide; In N,N-dimethyl-formamide;
DOI:10.1021/jm00171a006

Reference yield:

: 105852-50-4
3-(benzyloxycarbonyl)-4-(cyclohexylmethyl)-2,2-dimethyl-5-(iodomethyl)-(4S,5R)-1,3-oxazolidine

: 128901-30-4
(4S,5S)-5-((R)-2-Butylcarbamoyl-3-methyl-butyl)-4-cyclohexylmethyl-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LDA, 2.) HMPA / 1.) hexane, THF, 35 deg C, 30 min, 2.) 2 h

2: triethylamine, 1-hydroxybenzotriazole hydrate (HOBT), 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDC) / dimethylformamide

With N,N,N,N,N,N-hexamethylphosphoric triamide; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium diisopropyl amide; In N,N-dimethyl-formamide;
DOI:10.1021/jm00171a006

Reference yield:

: 105852-42-4,105864-88-8,130227-93-9
(2RS)-2-[(4S,5S)-3-benzyloxycarbonyl-4-cyclohexylmethyl-2,2-dimethyl-1,3-oxazolidin-5-yl]methyl-3-methylbutanoic acid

: 109-73-9,85404-21-3
N-butylamine

: 128901-30-4
(4S,5S)-5-((R)-2-Butylcarbamoyl-3-methyl-butyl)-4-cyclohexylmethyl-2,2-dimethyl-oxazolidine-3-carboxylic acid benzyl ester

: 105852-65-1
(2S)-2-[(4S,5S)-3-benzyloxycarbonyl-4-cyclohexylmethyl-2,2-dimethyl-1,3-oxazolidin-5-yl]methyl-N-butyl-3-methylbutanamide

Guidance literature:: With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; Yield given. Yields of byproduct given;
DOI:10.1021/jm00171a006