N,O-BIS(TERT-BUTYLDIMETHYLSILYL)ACETAMIDE

Base Information

• Chemical Name: N,O-BIS(TERT-BUTYLDIMETHYLSILYL)ACETAMIDE
• CAS No.: 82112-21-8
• Molecular Formula: C14H33 N O Si2
• Molecular Weight: 287.593
• Hs Code.: 2931900090
• Mol file: 82112-21-8.mol

Synonyms:N,O-BIS(DIMETHYL-T-BUTYLSILYL)ACETAMIDE;N,O-BIS(DIMETHYL-TERT-BUTYLSILYL)ACETAMIDE;N,O-BIS(TERT-BUTYLDIMETHYLSILYL)ACETAMIDE;Bisbutyldimethylsilylacetamide;tert-butyldimethylsilylatingagent;N,O-Bis(tert-butyldimethylsilyl)acetamide [tert-Butyldimethylsilylating Agent]

Chemical Property of N,O-BIS(TERT-BUTYLDIMETHYLSILYL)ACETAMIDE

Chemical Property:

• Vapor Pressure: 0.0053mmHg at 25°C
• Refractive Index: 1.423
• Boiling Point: 283.8°C at 760 mmHg
• PKA: 6.17±0.50(Predicted)
• Flash Point: 125.4°C
• PSA: 21.59000
• Density: 0.82g/cm³
• LogP: 5.43180
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

N,O-Bis(tert-butyldimethylsilyl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N,O-BIS(TERT-BUTYLDIMETHYLSILYL)ACETAMIDE

There total 1 articles about N,O-BIS(TERT-BUTYLDIMETHYLSILYL)ACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetamide (60-35-5) + tert-butyldimethylsilyl chloride (18162-48-6) → N,O-bis(tertbutyldimethylsilyl)acetamide (82112-21-8)

Guidance literature:

In triethylamine; Heating;

Reference yield: 97.0%

1-methyl-1-phenylethyl alcohol (617-94-7) + N,O-bis(tertbutyldimethylsilyl)acetamide (82112-21-8) → tert-butyldimethylsilyl ether of 2-phenyl-2-propanol (80534-13-0)

Guidance literature:

With tetrabutyl ammonium fluoride; In various solvent(s); for 16h; Ambient temperature;

DOI:10.1016/0040-4039(95)02232-5

Reference yield: 97.0%

N,O-bis(tertbutyldimethylsilyl)acetamide (82112-21-8) + trans-sobrerol (32226-54-3) → 2-[(1R,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-4-methyl-cyclohex-3-enyl]-propan-2-ol

Guidance literature:

With tetrabutyl ammonium fluoride; In various solvent(s); for 12h; Ambient temperature;

DOI:10.1016/0040-4039(95)02232-5

upstream raw materials:

acetamide

tert-butyldimethylsilyl chloride

Downstream raw materials:

2,2,3,3,8,8,9,9-octamethyl-5-phenyl-4,7-dioxa-3,8-disiladecane

tert-butyldimethylsilyl ether of 2-phenyl-2-propanol

methyl 6-O-(tert-butyldimethylsilyl)-α-D-glucopyranoside

6-O-tert-butyldimethylsilyl-D-glucal