(4-fluoro-phenylsulfanyl)-acetic acid 10-[(4-fluoro-phenylsulfanyl)-acetoxy]-13-{4-[(4-fluoro-phenylsulfanyl)-acetoxy]-3-methoxy-phenyl}-2,11-dimethoxy-6-oxo-7,8-dihydro-6H-5-oxa-6b-aza-dibenzo[a,i]fluoren-3-yl ester

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Chemical Name:(4-fluoro-phenylsulfanyl)-acetic acid 10-[(4-fluoro-phenylsulfanyl)-acetoxy]-13-{4-[(4-fluoro-phenylsulfanyl)-acetoxy]-3-methoxy-phenyl}-2,11-dimethoxy-6-oxo-7,8-dihydro-6H-5-oxa-6b-aza-dibenzo[a,i]fluoren-3-yl ester
CAS No.:660397-13-7
Molecular Formula:C₅₂H₃₈F₃NO₁₁S₃
Molecular Weight:1006.07
Hs Code.:

(4-fluoro-phenylsulfanyl)-acetic acid 10-[(4-fluoro-phenylsulfanyl)-acetoxy]-13-{4-[(4-fluoro-phenylsulfanyl)-acetoxy]-3-methoxy-phenyl}-2,11-dimethoxy-6-oxo-7,8-dihydro-6<i>H</i>-5-oxa-6b-aza-dibenzo[<i>a</i>,<i>i</i>]fluoren-3-yl ester

Synonyms:(4-fluoro-phenylsulfanyl)-acetic acid 10-[(4-fluoro-phenylsulfanyl)-acetoxy]-13-{4-[(4-fluoro-phenylsulfanyl)-acetoxy]-3-methoxy-phenyl}-2,11-dimethoxy-6-oxo-7,8-dihydro-6H-5-oxa-6b-aza-dibenzo[a,i]fluoren-3-yl ester

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Chemical Property of (4-fluoro-phenylsulfanyl)-acetic acid 10-[(4-fluoro-phenylsulfanyl)-acetoxy]-13-{4-[(4-fluoro-phenylsulfanyl)-acetoxy]-3-methoxy-phenyl}-2,11-dimethoxy-6-oxo-7,8-dihydro-6H-5-oxa-6b-aza-dibenzo[a,i]fluoren-3-yl ester

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Technology Process of (4-fluoro-phenylsulfanyl)-acetic acid 10-[(4-fluoro-phenylsulfanyl)-acetoxy]-13-{4-[(4-fluoro-phenylsulfanyl)-acetoxy]-3-methoxy-phenyl}-2,11-dimethoxy-6-oxo-7,8-dihydro-6H-5-oxa-6b-aza-dibenzo[a,i]fluoren-3-yl ester

There total 4 articles about (4-fluoro-phenylsulfanyl)-acetic acid 10-[(4-fluoro-phenylsulfanyl)-acetoxy]-13-{4-[(4-fluoro-phenylsulfanyl)-acetoxy]-3-methoxy-phenyl}-2,11-dimethoxy-6-oxo-7,8-dihydro-6H-5-oxa-6b-aza-dibenzo[a,i]fluoren-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 656836-79-2
14-(4-hydroxy-3-methoxyphenyl)-3,11-dihydroxy-2,12-dimethoxy-8,9-dihydro-6H-chromeno[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

: 332-51-4
(4-fluorophenylthio)acetic acid

: 660397-13-7
(4-fluoro-phenylsulfanyl)-acetic acid 10-[(4-fluoro-phenylsulfanyl)-acetoxy]-13-{4-[(4-fluoro-phenylsulfanyl)-acetoxy]-3-methoxy-phenyl}-2,11-dimethoxy-6-oxo-7,8-dihydro-6H-5-oxa-6b-aza-dibenzo[a,i]fluoren-3-yl ester

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 23 ℃; for 2h;
DOI:10.1016/j.bmc.2004.01.020

Reference yield:

: 6-isopropoxy-7-methoxy-3,4-dihydroisoquinoline

: 660397-13-7
(4-fluoro-phenylsulfanyl)-acetic acid 10-[(4-fluoro-phenylsulfanyl)-acetoxy]-13-{4-[(4-fluoro-phenylsulfanyl)-acetoxy]-3-methoxy-phenyl}-2,11-dimethoxy-6-oxo-7,8-dihydro-6H-5-oxa-6b-aza-dibenzo[a,i]fluoren-3-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,2-dichloro-ethane / 8 h / 23 °C

1.2: 47 percent / DIPEA / 1,2-dichloro-ethane / 32 h / 85 °C

2.1: 97 percent / AlCl₃ / CH₂Cl₂ / 2.5 h / 23 °C

3.1: 94 percent / EDC*HCl; DMAP / CH₂Cl₂ / 2 h / 23 °C

With dmap; aluminium trichloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/j.bmc.2004.01.020

Reference yield:

: 660396-69-0
5,6-dihydro-3,11-diisopropoxy-14-(4-isopropoxy-3-methoxyphenyl)-2,12-dimethoxy-6H-[1]benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

: 660397-13-7
(4-fluoro-phenylsulfanyl)-acetic acid 10-[(4-fluoro-phenylsulfanyl)-acetoxy]-13-{4-[(4-fluoro-phenylsulfanyl)-acetoxy]-3-methoxy-phenyl}-2,11-dimethoxy-6-oxo-7,8-dihydro-6H-5-oxa-6b-aza-dibenzo[a,i]fluoren-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / AlCl₃ / CH₂Cl₂ / 2.5 h / 23 °C

2: 94 percent / EDC*HCl; DMAP / CH₂Cl₂ / 2 h / 23 °C

With dmap; aluminium trichloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;
DOI:10.1016/j.bmc.2004.01.020