methyl 3-(4-(4'-((5-(tert-butyl)-1,3,4-oxadiazol-2-yl)amino)-[1,1'-biphenyl]-4-yl)-7-oxabicyclo[2.2.1]heptan-1-yl)propanoate

Base Information

Chemical Name:methyl 3-(4-(4'-((5-(tert-butyl)-1,3,4-oxadiazol-2-yl)amino)-[1,1'-biphenyl]-4-yl)-7-oxabicyclo[2.2.1]heptan-1-yl)propanoate
CAS No.:1477524-79-0
Molecular Formula:C₂₈H₃₃N₃O₄
Molecular Weight:475.588
Hs Code.:

Synonyms:methyl 3-(4-(4'-((5-(tert-butyl)-1,3,4-oxadiazol-2-yl)amino)-[1,1'-biphenyl]-4-yl)-7-oxabicyclo[2.2.1]heptan-1-yl)propanoate

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Chemical Property of methyl 3-(4-(4'-((5-(tert-butyl)-1,3,4-oxadiazol-2-yl)amino)-[1,1'-biphenyl]-4-yl)-7-oxabicyclo[2.2.1]heptan-1-yl)propanoate

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Technology Process of methyl 3-(4-(4'-((5-(tert-butyl)-1,3,4-oxadiazol-2-yl)amino)-[1,1'-biphenyl]-4-yl)-7-oxabicyclo[2.2.1]heptan-1-yl)propanoate

There total 4 articles about methyl 3-(4-(4'-((5-(tert-butyl)-1,3,4-oxadiazol-2-yl)amino)-[1,1'-biphenyl]-4-yl)-7-oxabicyclo[2.2.1]heptan-1-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1477524-78-9
methyl 3-(4-(4-bromophenyl)-7-oxabicyclo[2.2.1]heptan-1-yl)propanoate

: 1477524-57-4
(5-tert-butyl-[1,3,4]oxadiazol-2-yl)-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)phenyl]amine

: 1477524-79-0
methyl 3-(4-(4'-((5-(tert-butyl)-1,3,4-oxadiazol-2-yl)amino)-[1,1'-biphenyl]-4-yl)-7-oxabicyclo[2.2.1]heptan-1-yl)propanoate

Guidance literature:: With bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); cesium fluoride; In 1,4-dioxane; water; at 90 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1477524-76-7
1-(4-bromophenyl)-4-(iodomethyl)-7-oxabicyclo[2.2.1]heptane

: 1477524-79-0
methyl 3-(4-(4'-((5-(tert-butyl)-1,3,4-oxadiazol-2-yl)amino)-[1,1'-biphenyl]-4-yl)-7-oxabicyclo[2.2.1]heptan-1-yl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 0.5 h / 20 °C / Cooling with ice

1.2: 0.75 h / 150 °C / Microwave irradiation

2.1: cesium fluoride; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / water; 1,4-dioxane / 2 h / 90 °C / Inert atmosphere

With bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); sodium hydride; cesium fluoride; In 1,4-dioxane; N,N-dimethyl acetamide; water; mineral oil; 2.1: |Suzuki Coupling;

Reference yield:

: 1477524-75-6
1-(4-bromophenyl)-4-methylenecyclohexanol

: 1477524-79-0
methyl 3-(4-(4'-((5-(tert-butyl)-1,3,4-oxadiazol-2-yl)amino)-[1,1'-biphenyl]-4-yl)-7-oxabicyclo[2.2.1]heptan-1-yl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: iodine; sodium carbonate / acetonitrile / 4.33 h / 20 °C

2.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 0.5 h / 20 °C / Cooling with ice

2.2: 0.75 h / 150 °C / Microwave irradiation

3.1: cesium fluoride; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / water; 1,4-dioxane / 2 h / 90 °C / Inert atmosphere

With bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); iodine; sodium hydride; sodium carbonate; cesium fluoride; In 1,4-dioxane; N,N-dimethyl acetamide; water; acetonitrile; mineral oil; 3.1: |Suzuki Coupling;