dimethyl 2-((4-(4-bromophenyl)-7-oxabicyclo[2.2.1]heptan-1-yl)methyl)malonate

Base Information

Chemical Name:dimethyl 2-((4-(4-bromophenyl)-7-oxabicyclo[2.2.1]heptan-1-yl)methyl)malonate
CAS No.:1477524-77-8
Molecular Formula:C₁₈H₂₁BrO₅
Molecular Weight:397.266
Hs Code.:

Synonyms:dimethyl 2-((4-(4-bromophenyl)-7-oxabicyclo[2.2.1]heptan-1-yl)methyl)malonate

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Chemical Property of dimethyl 2-((4-(4-bromophenyl)-7-oxabicyclo[2.2.1]heptan-1-yl)methyl)malonate

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Technology Process of dimethyl 2-((4-(4-bromophenyl)-7-oxabicyclo[2.2.1]heptan-1-yl)methyl)malonate

There total 5 articles about dimethyl 2-((4-(4-bromophenyl)-7-oxabicyclo[2.2.1]heptan-1-yl)methyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1477524-76-7
1-(4-bromophenyl)-4-(iodomethyl)-7-oxabicyclo[2.2.1]heptane

: 108-59-8
malonic acid dimethyl ester

: 1477524-77-8
dimethyl 2-((4-(4-bromophenyl)-7-oxabicyclo[2.2.1]heptan-1-yl)methyl)malonate

: 1477524-78-9
methyl 3-(4-(4-bromophenyl)-7-oxabicyclo[2.2.1]heptan-1-yl)propanoate

Guidance literature:: malonic acid dimethyl ester; With sodium hydride; In N,N-dimethyl acetamide; mineral oil; at 20 ℃; for 0.5h; Cooling with ice;

1-(4-bromophenyl)-4-(iodomethyl)-7-oxabicyclo[2.2.1]heptane; In N,N-dimethyl acetamide; mineral oil; at 150 ℃; for 0.75h; Microwave irradiation;

Reference yield:

: 1477524-75-6
1-(4-bromophenyl)-4-methylenecyclohexanol

: 1477524-77-8
dimethyl 2-((4-(4-bromophenyl)-7-oxabicyclo[2.2.1]heptan-1-yl)methyl)malonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: iodine; sodium carbonate / acetonitrile / 4.33 h / 20 °C

2.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 0.5 h / 20 °C / Cooling with ice

2.2: 0.75 h / 150 °C / Microwave irradiation

With iodine; sodium hydride; sodium carbonate; In N,N-dimethyl acetamide; acetonitrile; mineral oil;

Reference yield:

: 51656-90-7
8-methylene-1,4-dioxaspiro[4.5]decane

: 1477524-77-8
dimethyl 2-((4-(4-bromophenyl)-7-oxabicyclo[2.2.1]heptan-1-yl)methyl)malonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid / acetone / 8 h / 50 °C

2.1: magnesium; iodine / tetrahydrofuran / 1.5 h / 20 °C

2.2: 3.83 h / -78 - 20 °C

3.1: iodine; sodium carbonate / acetonitrile / 4.33 h / 20 °C

4.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 0.5 h / 20 °C / Cooling with ice

4.2: 0.75 h / 150 °C / Microwave irradiation

With iodine; sodium hydride; sodium carbonate; toluene-4-sulfonic acid; magnesium; In tetrahydrofuran; N,N-dimethyl acetamide; acetone; acetonitrile; mineral oil;