Technology Process of 3-(4-(4'-((5-(tert-butyl)-1,3,4-oxadiazol-2-yl)amino)-[1,1'-biphenyl]-4-yl)-7-oxabicyclo[2.2.1]heptan-1-yl)propanoic acid
There total 6 articles about 3-(4-(4'-((5-(tert-butyl)-1,3,4-oxadiazol-2-yl)amino)-[1,1'-biphenyl]-4-yl)-7-oxabicyclo[2.2.1]heptan-1-yl)propanoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
methanol; sodium hydroxide;
In
tetrahydrofuran;
at 20 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 0.5 h / 20 °C / Cooling with ice
1.2: 0.75 h / 150 °C / Microwave irradiation
2.1: cesium fluoride; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / water; 1,4-dioxane / 2 h / 90 °C / Inert atmosphere
3.1: methanol; sodium hydroxide / tetrahydrofuran / 2 h / 20 °C
With
methanol; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); sodium hydride; cesium fluoride; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; N,N-dimethyl acetamide; water; mineral oil;
2.1: |Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: magnesium; iodine / tetrahydrofuran / 1.5 h / 20 °C
1.2: 3.83 h / -78 - 20 °C
2.1: iodine; sodium carbonate / acetonitrile / 4.33 h / 20 °C
3.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 0.5 h / 20 °C / Cooling with ice
3.2: 0.75 h / 150 °C / Microwave irradiation
4.1: cesium fluoride; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / water; 1,4-dioxane / 2 h / 90 °C / Inert atmosphere
5.1: methanol; sodium hydroxide / tetrahydrofuran / 2 h / 20 °C
With
methanol; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); iodine; sodium hydride; sodium carbonate; magnesium; cesium fluoride; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; N,N-dimethyl acetamide; water; acetonitrile; mineral oil;
4.1: |Suzuki Coupling;