Technology Process of 1-(4-bromophenyl)-4-(iodomethyl)-7-oxabicyclo[2.2.1]heptane
There total 4 articles about 1-(4-bromophenyl)-4-(iodomethyl)-7-oxabicyclo[2.2.1]heptane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
iodine; sodium carbonate;
In
acetonitrile;
at 20 ℃;
for 4.33h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: toluene-4-sulfonic acid / acetone / 8 h / 50 °C
2.1: magnesium; iodine / tetrahydrofuran / 1.5 h / 20 °C
2.2: 3.83 h / -78 - 20 °C
3.1: iodine; sodium carbonate / acetonitrile / 4.33 h / 20 °C
With
iodine; sodium carbonate; toluene-4-sulfonic acid; magnesium;
In
tetrahydrofuran; acetone; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium tert-butylate / water; 1,4-dioxane / 1.25 h / 0 - 20 °C
2.1: toluene-4-sulfonic acid / acetone / 8 h / 50 °C
3.1: magnesium; iodine / tetrahydrofuran / 1.5 h / 20 °C
3.2: 3.83 h / -78 - 20 °C
4.1: iodine; sodium carbonate / acetonitrile / 4.33 h / 20 °C
With
potassium tert-butylate; iodine; sodium carbonate; toluene-4-sulfonic acid; magnesium;
In
tetrahydrofuran; 1,4-dioxane; water; acetone; acetonitrile;
1.1: |Wittig Olefination;