3,5-dimethyl-4-trans-styrylisoxazole

Base Information

• Chemical Name: 3,5-dimethyl-4-trans-styrylisoxazole
• CAS No.: 81190-81-0
• Molecular Formula: C₁₃H₁₃NO
• Molecular Weight: 199.252
• Mol file: 81190-81-0.mol

Synonyms:3,5-dimethyl-4-trans-styrylisoxazole

Chemical Property of 3,5-dimethyl-4-trans-styrylisoxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-dimethyl-4-trans-styrylisoxazole

There total 5 articles about 3,5-dimethyl-4-trans-styrylisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4-Iodoacetophenone (13329-40-3) + 1,3-bis((E)-4-methoxystyryl)-1,1,3,3-tetramethyldisiloxane (1147765-35-2) → 3,5-dimethyl-4-trans-styrylisoxazole (81190-81-0)

Guidance literature:

With potassium hydroxide; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In methanol; optical yield given as %de;

DOI:10.1039/b900852g

Reference yield: 68.0%

3,5-dimethyl-1,2-oxazole (300-87-8) + styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) → 3,5-dimethyl-4-trans-styrylisoxazole (81190-81-0)

Guidance literature:

With copper diacetate; palladium diacetate; In N,N-dimethyl acetamide; at 120 ℃; for 1h;

DOI:10.1016/j.tetlet.2011.04.051

Reference yield: 53.0%

4-iodo-3,5-dimethylisoxazole (10557-85-4) + trans,trans-1,7-diphenyl-3,3,5,5-tetramethyl-3,5-disila-4-oxahepta-1,6-diene (72761-85-4) → 3,5-dimethyl-4-trans-styrylisoxazole (81190-81-0)

Guidance literature:

With potassium hydroxide; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In methanol; optical yield given as %de;

DOI:10.1039/b900852g

upstream raw materials:

styrene

4-iodo-3,5-dimethylisoxazole

trans,trans-1,7-diphenyl-3,3,5,5-tetramethyl-3,5-disila-4-oxahepta-1,6-diene

4-Iodoacetophenone

Refernces

• 1、 Chappell, Ben,Dedman, Nathan,Wheeler, Simon. "Studies on the palladium-catalysed direct alkenylation of 1,2-azoles". experimental part. p. 3223 - 3225. Retrieved 2011/06/28.
• 2、 Yamanaka, Hiroshi,Shiraiwa, Masafumi,Yamamoto, Etsuko,Sakamoto, Takao. "CROSS-COUPLING REACTIONS OF HALOISOXAZOLES WITH OLEFINS AND ACETYLENES". . p. 3543 - 3547. Retrieved 2007/10/02.