Tyrosylglycine

Base Information

• Chemical Name: Tyrosylglycine
• CAS No.: 673-08-5
• Molecular Formula: C11H14 N2 O4
• Molecular Weight: 238.243
• Hs Code.: 2924299090
• NSC Number: 89184
• Mol file: 673-08-5.mol

Synonyms:tyrosylglycine;2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetic acid;NSC-89184;NSC89184;SCHEMBL4409294;HPYDSVWYXXKHRD-UHFFFAOYSA-N;YG;FT-0773219

Chemical Property of Tyrosylglycine

Chemical Property:

• Vapor Pressure: 8.72E-15mmHg at 25°C
• Melting Point: 260-264℃
• Boiling Point: 590.4°C at 760 mmHg
• PKA: 3.11±0.10(Predicted)
• Flash Point: 310.9°C
• PSA: 112.65000
• Density: 1.362
• LogP: 0.55400
• Storage Temp.: -15°C
• XLogP3: -2.9
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 238.09535693
• Heavy Atom Count: 17
• Complexity: 275

Purity/Quality:

97% ^*data from raw suppliers

Tyr-Gly-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1CC(C(=O)NCC(=O)O)N)O

Technology Process of Tyrosylglycine

There total 13 articles about Tyrosylglycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

leucine enkephalin acetate (81678-16-2) → L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) + YG (673-08-5) + L-Phe-Leu (3303-55-7) + tyrosylglycylglycine (21778-69-8) + L-tyrosine (60-18-4,18875-48-4,25619-78-7,30704-25-7) + [des-tyr1]-leucine enkephalin (60254-83-3)

Guidance literature:

In water; at 37 ℃; for 6h; Product distribution; Rate constant; enzymes: leucine aminopeptidase , carboxypeptidase B; degradation in extracts of various mucosae (nasal, rectal, vaginal); female White Albino rabbits; different inhibitors (amastatin, thimerosal, thiorphan); pH=5-8;

DOI:10.1002/jps.2600821124

Reference yield:

(S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methylsulfanyl-butyric acid; compound with acetic acid (82362-17-2) → L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) + YG (673-08-5) + Phe-Met (15080-84-9) + tyrosylglycylglycine (21778-69-8) + L-tyrosine (60-18-4,18875-48-4,25619-78-7,30704-25-7) + [des-tyr1]-methionine enkephalin (61370-88-5)

Guidance literature:

With aq. buffer; at 37 ℃; Rate constant; Kinetics; also reaction in the presence of var. rabbit mucosal extracts, var. temp. and pH;

DOI:10.1002/jps.2600820408

Reference yield:

-enkephalyl-arg6-phe7 → YG (673-08-5) + met-enkephalin (58569-55-4) + tyrosylglycylglycine (21778-69-8) + L-tyrosine (60-18-4,18875-48-4,25619-78-7,30704-25-7)

Guidance literature:

With membrane fraction; In various solvents; at 37 ℃; for 1h; pH=7.4; Further Variations:; Reagents; Product distribution;

DOI:10.1007/PL00005168

upstream raw materials:

L-Tyr(OAc) NCA

GlyOEt*HCl

N-benzyloxycarbonyl-(S)-tyrosinyl-glycine

(S)-2-(2-(((benzyloxy)carbonyl)amino)-3-(4-(benzyloxy)phenyl)propanamido)acetic acid

Downstream raw materials:

benzyl methyl ether

glycine

3,4-dihydroxyphenylalanyl glycine

N-(thiophene-2-acetyl)-L-tyrosylglycine