(S)-1-{4-[Bis-(4-fluoro-phenyl)-methyl]-piperazin-1-yl}-2-(4-tert-butoxy-benzylamino)-4-methyl-pentan-1-one

Base Information

Chemical Name:(S)-1-{4-[Bis-(4-fluoro-phenyl)-methyl]-piperazin-1-yl}-2-(4-tert-butoxy-benzylamino)-4-methyl-pentan-1-one
CAS No.:248922-27-2
Molecular Formula:C₃₄H₄₃F₂N₃O₂
Molecular Weight:563.731
Hs Code.:

Synonyms:(S)-1-{4-[Bis-(4-fluoro-phenyl)-methyl]-piperazin-1-yl}-2-(4-tert-butoxy-benzylamino)-4-methyl-pentan-1-one

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Chemical Property of (S)-1-{4-[Bis-(4-fluoro-phenyl)-methyl]-piperazin-1-yl}-2-(4-tert-butoxy-benzylamino)-4-methyl-pentan-1-one

Chemical Property:

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Technology Process of (S)-1-{4-[Bis-(4-fluoro-phenyl)-methyl]-piperazin-1-yl}-2-(4-tert-butoxy-benzylamino)-4-methyl-pentan-1-one

There total 4 articles about (S)-1-{4-[Bis-(4-fluoro-phenyl)-methyl]-piperazin-1-yl}-2-(4-tert-butoxy-benzylamino)-4-methyl-pentan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 248922-15-8
(S)-2-amino-1-{4-[bis-(4-fluoro-phenyl)-methyl]-piperazin-1-yl}-4-methyl-pentan-1-one

: 144-55-8
sodium hydrogencarbonate

: 57699-45-3
p-tert-butoxybenzaldehyde

: 248922-27-2
(S)-1-{4-[Bis-(4-fluoro-phenyl)-methyl]-piperazin-1-yl}-2-(4-tert-butoxy-benzylamino)-4-methyl-pentan-1-one

Guidance literature:: With sodium tris(acetoxy)borohydride; In dichloromethane; ethyl acetate;

Reference yield:

: 248922-12-5
(S)-(1-{4-[Bis-(4-fluoro-phenyl)-methyl]-piperazine-1-carbonyl}-3-methyl-butyl)-carbamic acid tert-butyl ester

: 248922-27-2
(S)-1-{4-[Bis-(4-fluoro-phenyl)-methyl]-piperazin-1-yl}-2-(4-tert-butoxy-benzylamino)-4-methyl-pentan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane

2: sodium tris(acetoxy)borohydride / dichloromethane; ethyl acetate

With sodium tris(acetoxy)borohydride; trifluoroacetic acid; In dichloromethane; ethyl acetate;

Reference yield:

: 200937-21-9
N-tert-butoxycarbonyl-L-leucine monohydrate

: 248922-27-2
(S)-1-{4-[Bis-(4-fluoro-phenyl)-methyl]-piperazin-1-yl}-2-(4-tert-butoxy-benzylamino)-4-methyl-pentan-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / diethyl ether; ethyl acetate; N,N-dimethyl-formamide

2: trifluoroacetic acid / dichloromethane

3: sodium tris(acetoxy)borohydride / dichloromethane; ethyl acetate

With sodium tris(acetoxy)borohydride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;