[1-(4-tert-butoxy-benzyl)-3-hydroxy-pent-4-enyl]-carbamic acid tert-butyl ester

Base Information

• Chemical Name: [1-(4-tert-butoxy-benzyl)-3-hydroxy-pent-4-enyl]-carbamic acid tert-butyl ester
• CAS No.: 507276-94-0
• Molecular Formula: C₂₁H₃₃NO₄
• Molecular Weight: 363.497
• Mol file: 507276-94-0.mol

Synonyms:[1-(4-tert-butoxy-benzyl)-3-hydroxy-pent-4-enyl]-carbamic acid tert-butyl ester

Chemical Property of [1-(4-tert-butoxy-benzyl)-3-hydroxy-pent-4-enyl]-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [1-(4-tert-butoxy-benzyl)-3-hydroxy-pent-4-enyl]-carbamic acid tert-butyl ester

There total 5 articles about [1-(4-tert-butoxy-benzyl)-3-hydroxy-pent-4-enyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[1-(4-tert-butoxy-benzyl)-3-diazo-2-oxo-propyl]-carbamic acid tert-butylester (565430-72-0) → [1-(4-tert-butoxy-benzyl)-3-hydroxy-pent-4-enyl]-carbamic acid tert-butyl ester (507276-94-0)

Guidance literature:

Multi-step reaction with 3 steps

1: PhCO₂Ag; NEt₃ / 1.25 h

2: DIBAL-H / toluene / 1 h / -78 °C

3: tetrahydrofuran / 1.5 h / -78 - -40 °C

With silver benzoate; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; toluene;

DOI:10.1021/ol027237f

Reference yield:

Boc-D-Tyr(t-Bu)-OH (507276-74-6) → [1-(4-tert-butoxy-benzyl)-3-hydroxy-pent-4-enyl]-carbamic acid tert-butyl ester (507276-94-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: isobutylchloroformate; N-methylmorpholine / tetrahydrofuran / 0.33 h / -20 °C

1.2: tetrahydrofuran; diethyl ether / 0.5 h / -20 °C

2.1: PhCO₂Ag; NEt₃ / 1.25 h

3.1: DIBAL-H / toluene / 1 h / -78 °C

4.1: tetrahydrofuran / 1.5 h / -78 - -40 °C

With 4-methyl-morpholine; silver benzoate; diisobutylaluminium hydride; triethylamine; isobutyl chloroformate; In tetrahydrofuran; toluene; 1.2: Arndt-Eistert homologation;

DOI:10.1021/ol027237f

Reference yield:

3-tert-butoxycarbonylamino-4-(4-tert-butoxy-phenyl)-butyric acid methyl ester (565430-82-2) → [1-(4-tert-butoxy-benzyl)-3-hydroxy-pent-4-enyl]-carbamic acid tert-butyl ester (507276-94-0)

Guidance literature:

Multi-step reaction with 2 steps

1: DIBAL-H / toluene / 1 h / -78 °C

2: tetrahydrofuran / 1.5 h / -78 - -40 °C

With diisobutylaluminium hydride; In tetrahydrofuran; toluene;

DOI:10.1021/ol027237f

upstream raw materials:

vinyl magnesium bromide

[1-(4-tert-butoxy-benzyl)-3-oxo-propyl]-carbamic acid tert-butyl ester

Boc-D-Tyr(t-Bu)-OH

3-tert-butoxycarbonylamino-4-(4-tert-butoxy-phenyl)-butyric acid methyl ester