N-[2-chloro-5-(trifluoromethyl)phenyl]-3-hydroxynaphthalene-2-carboxamide

Base Information

• Chemical Name: N-[2-chloro-5-(trifluoromethyl)phenyl]-3-hydroxynaphthalene-2-carboxamide
• CAS No.: 398-11-8
• Molecular Formula: C₁₈H₁₁ClF₃NO₂
• Molecular Weight: 365.739
• Mol file: 398-11-8.mol

Synonyms:N-[2-chloro-5-(trifluoromethyl)phenyl]-3-hydroxynaphthalene-2-carboxamide

Chemical Property of N-[2-chloro-5-(trifluoromethyl)phenyl]-3-hydroxynaphthalene-2-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of N-[2-chloro-5-(trifluoromethyl)phenyl]-3-hydroxynaphthalene-2-carboxamide

There total 2 articles about N-[2-chloro-5-(trifluoromethyl)phenyl]-3-hydroxynaphthalene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

3-Hydroxy-2-naphthoic acid (92-70-6) + 3-amino-4-chlorobenzotrifluoride (121-50-6) → N-[2-chloro-5-(trifluoromethyl)phenyl]-3-hydroxynaphthalene-2-carboxamide (398-11-8)

Guidance literature:

With phosphorus trichloride; In chlorobenzene; at 100 - 130 ℃; for 0.75h; Microwave irradiation;

DOI:10.3390/ijms21186583

Reference yield:

3-Hydroxy-2-naphthoic acid (92-70-6) → N-[2-chloro-5-(trifluoromethyl)phenyl]-3-hydroxynaphthalene-2-carboxamide (398-11-8)

Guidance literature:

With toluene; trichlorophosphate;

Reference yield:

3-amino-4-methoxybenzoic acid phenylamide (120-35-4) + N-[2-chloro-5-(trifluoromethyl)phenyl]-3-hydroxynaphthalene-2-carboxamide (398-11-8) → C32H22ClF3N4O4

Guidance literature:

N-[2-chloro-5-(trifluoromethyl)phenyl]-3-hydroxynaphthalene-2-carboxamide; With sodium hydroxide; In methanol; water;

3-amino-4-methoxybenzoic acid phenylamide; With hydrogenchloride; acetic acid; sodium nitrite; In methanol; water; at 5 ℃; Further stages;

upstream raw materials:

3-Hydroxy-2-naphthoic acid

3-amino-4-chlorobenzotrifluoride