(S)-methyl 2-(2,5-dihydro-1H-pyrrol-1-yl)-3-phenylpropanoate

Base Information

• Chemical Name: (S)-methyl 2-(2,5-dihydro-1H-pyrrol-1-yl)-3-phenylpropanoate
• CAS No.: 847899-98-3
• Molecular Formula: C₁₄H₁₇NO₂
• Molecular Weight: 231.294
• Mol file: 847899-98-3.mol

Synonyms:(S)-methyl 2-(2,5-dihydro-1H-pyrrol-1-yl)-3-phenylpropanoate

Chemical Property of (S)-methyl 2-(2,5-dihydro-1H-pyrrol-1-yl)-3-phenylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of (S)-methyl 2-(2,5-dihydro-1H-pyrrol-1-yl)-3-phenylpropanoate

There total 5 articles about (S)-methyl 2-(2,5-dihydro-1H-pyrrol-1-yl)-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N,N-bis-allyl-L-phenylalanine methyl ester (79561-72-1) → (S)-methyl 2-(2,5-dihydro-1H-pyrrol-1-yl)-3-phenylpropanoate (847899-98-3)

Guidance literature:

With titanium(IV) isopropylate; tri(cycloxexyl)phosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene][benzylidene]ruthenium(IV) dichloride; In dichloromethane; at 40 ℃; for 6h; Further Variations:; Reagents; Product distribution;

DOI:10.1021/ol047356q

Reference yield: 65.0%

Z-1,4-dichlorobutene (1476-11-5) + methyl (2S)-2-amino-3-phenylpropanoate (2577-90-4) → (S)-methyl 2-(2,5-dihydro-1H-pyrrol-1-yl)-3-phenylpropanoate (847899-98-3)

Guidance literature:

In dichloromethane; at 20 ℃; for 24h;

DOI:10.1055/s-2006-958408

Reference yield: 57.0%

N,N-bis-allyl-L-phenylalanine methyl ester (79561-72-1) → methyl (S)-3-phenyl-2-(1H-pyrrol-1-yl)propanoate (116763-08-7) + (S)-methyl 2-(2,5-dihydro-1H-pyrrol-1-yl)-3-phenylpropanoate (847899-98-3)

Guidance literature:

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; at 150 ℃; for 0.166667h; microwave irradiation;

DOI:10.1016/j.tetlet.2006.03.164

upstream raw materials:

N,N-bis-allyl-L-phenylalanine methyl ester

Z-1,4-dichlorobutene

methyl (2S)-2-amino-3-phenylpropanoate

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride