1-benzyl-4-dimethoxymethyl-3-(4-methylbenzyl)-3-(toluene-4-sulfonyl)piperidin-2-one

Base Information

• Chemical Name: 1-benzyl-4-dimethoxymethyl-3-(4-methylbenzyl)-3-(toluene-4-sulfonyl)piperidin-2-one
• CAS No.: 808141-13-1
• Molecular Formula: C₃₀H₃₅NO₅S
• Molecular Weight: 521.678

Synonyms:1-benzyl-4-dimethoxymethyl-3-(4-methylbenzyl)-3-(toluene-4-sulfonyl)piperidin-2-one

Chemical Property of 1-benzyl-4-dimethoxymethyl-3-(4-methylbenzyl)-3-(toluene-4-sulfonyl)piperidin-2-one

Chemical Property:

Purity/Quality:

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Technology Process of 1-benzyl-4-dimethoxymethyl-3-(4-methylbenzyl)-3-(toluene-4-sulfonyl)piperidin-2-one

There total 4 articles about 1-benzyl-4-dimethoxymethyl-3-(4-methylbenzyl)-3-(toluene-4-sulfonyl)piperidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-Methylbenzyl bromide (104-81-4) + 1-benzyl-4-dimethoxymethyl-3-(toluene-4-sulfonyl)piperidin-2-one (640722-73-2) → 1-benzyl-4-dimethoxymethyl-3-(4-methylbenzyl)-3-(toluene-4-sulfonyl)piperidin-2-one (808141-13-1)

Guidance literature:

With sodium hydride; sodium iodide; In tetrahydrofuran; Heating;

DOI:10.1016/j.tet.2004.09.015

Reference yield:

(E)-4,4-dimethoxy-but-2-enoic acid ethyl ester (19255-60-8,114736-26-4,114736-25-3) → 1-benzyl-4-dimethoxymethyl-3-(4-methylbenzyl)-3-(toluene-4-sulfonyl)piperidin-2-one (808141-13-1)

Guidance literature:

Multi-step reaction with 3 steps

1: base / 20 °C

2: LiAlH₄; Et₃N / Heating

3: 85 percent / NaH; NaI / tetrahydrofuran / Heating

With lithium aluminium tetrahydride; sodium hydride; triethylamine; sodium iodide; In tetrahydrofuran;

DOI:10.1016/j.tet.2004.09.015

Reference yield:

N-benzyl-2-(4-methylphenylsulfonyl)acetamide (330173-08-5) → 1-benzyl-4-dimethoxymethyl-3-(4-methylbenzyl)-3-(toluene-4-sulfonyl)piperidin-2-one (808141-13-1)

Guidance literature:

Multi-step reaction with 3 steps

1: base / 20 °C

2: LiAlH₄; Et₃N / Heating

3: 85 percent / NaH; NaI / tetrahydrofuran / Heating

With lithium aluminium tetrahydride; sodium hydride; triethylamine; sodium iodide; In tetrahydrofuran;

DOI:10.1016/j.tet.2004.09.015

upstream raw materials:

4-Methylbenzyl bromide

1-benzyl-4-dimethoxymethyl-3-(toluene-4-sulfonyl)piperidin-2-one

(E)-4,4-dimethoxy-but-2-enoic acid ethyl ester

N-benzyl-2-(4-methylphenylsulfonyl)acetamide

Downstream raw materials:

1-benzyl-3-(4-methylbenzyl)-2-oxo-1,2,5,6-tetrahydropyridine-4-carbaldehyde

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