4(S)-butyl-3-<2(S)-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1-oxo-3-phenylpropyl>-5-oxazolidinone

Base Information

Chemical Name:4(S)-butyl-3-<2(S)-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1-oxo-3-phenylpropyl>-5-oxazolidinone
CAS No.:138571-20-7
Molecular Formula:C₂₄H₂₄N₂O₅
Molecular Weight:420.465
Hs Code.:

Synonyms:4(S)-butyl-3-<2(S)-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1-oxo-3-phenylpropyl>-5-oxazolidinone

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Chemical Property of 4(S)-butyl-3-<2(S)-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1-oxo-3-phenylpropyl>-5-oxazolidinone

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Technology Process of 4(S)-butyl-3-<2(S)-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1-oxo-3-phenylpropyl>-5-oxazolidinone

There total 4 articles about 4(S)-butyl-3-<2(S)-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1-oxo-3-phenylpropyl>-5-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 138571-19-4
N-phthaloyl-L-phenylalaninylnorleucine

: 138571-20-7
4(S)-butyl-3-<2(S)-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1-oxo-3-phenylpropyl>-5-oxazolidinone

Guidance literature:: With toluene-4-sulfonic acid; In benzene; for 6h; Heating;
DOI:10.1021/jm00083a006

Reference yield:

: 3844-54-0
L-2-aminohexanoic acid-methyl ester hydrochloride

: 138571-20-7
4(S)-butyl-3-<2(S)-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1-oxo-3-phenylpropyl>-5-oxazolidinone

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) triethylamine, N-hydroxybenzotriazole, 2.) 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / 1.) CH₂Cl₂, 2.) CH₂Cl₂, RT, overnight

2: 60 percent / aq. HCl / acetone / 5 h / Heating

3: 63 percent / p-toluenesulfonic acid / benzene / 6 h / Heating

With hydrogenchloride; benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In acetone; benzene;
DOI:10.1021/jm00083a006

Reference yield:

: 138571-18-3
N-phthaloyl-L-phenylalanine-L-norleucine methyl ester

: 138571-20-7
4(S)-butyl-3-<2(S)-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1-oxo-3-phenylpropyl>-5-oxazolidinone

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / aq. HCl / acetone / 5 h / Heating

2: 63 percent / p-toluenesulfonic acid / benzene / 6 h / Heating

With hydrogenchloride; toluene-4-sulfonic acid; In acetone; benzene;
DOI:10.1021/jm00083a006