2,3,5,6-Tetrafluoro-4-phenylpyridine

Base Information

• Chemical Name: 2,3,5,6-Tetrafluoro-4-phenylpyridine
• CAS No.: 2875-19-6
• Molecular Formula: C₁₁H₅F₄N
• Molecular Weight: 227.161
• DSSTox Substance ID: DTXSID801289259
• Nikkaji Number: J2.763.211D
• Mol file: 2875-19-6.mol

Synonyms:2875-19-6;2,3,5,6-Tetrafluoro-4-phenylpyridine;4-Phenyl-2,3,5,6-tetrafluoropyridine;SCHEMBL21544310;DTXSID801289259

Chemical Property of 2,3,5,6-Tetrafluoro-4-phenylpyridine

Chemical Property:

• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 227.03581181
• Heavy Atom Count: 16
• Complexity: 218

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=C(C(=NC(=C2F)F)F)F

Technology Process of 2,3,5,6-Tetrafluoro-4-phenylpyridine

There total 22 articles about 2,3,5,6-Tetrafluoro-4-phenylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

Pentafluoropyridine (700-16-3) + Phenyl triflate (17763-67-6) → 2,3,5,6-tetrafluoro-4-phenyl-pyridine (2875-19-6)

Guidance literature:

Pentafluoropyridine; With H₂SiEt₂; tetrabutylammonium triphenyldifluorosilicate; In tetrahydrofuran; benzene-d6; at 40 ℃; for 20h; Inert atmosphere; Sealed tube;

Phenyl triflate; With potassium acetate; palladium diacetate; 2-(dicyclohexylphosphino)-2'-methylbiphenyl; In tetrahydrofuran; benzene-d6; at 60 ℃; for 20h; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.201708003

Reference yield: 85.0%

Pentafluoropyridine (700-16-3) + phenylmagnesium bromide (100-58-3) → 2,3,5,6-tetrafluoro-4-phenyl-pyridine (2875-19-6)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/om4011609

Reference yield: 81.0%

2,3,5,6-tetrafluoropyridine (2875-18-5) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → 2,3,5,6-tetrafluoro-4-phenyl-pyridine (2875-19-6)

Guidance literature:

With diisopropylsulfide; palladium diacetate; acetic acid; silver carbonate; at 120 ℃; for 20h; Inert atmosphere;

DOI:10.1021/ol102688e

upstream raw materials:

2,3,5,6-tetrafluoropyridin-4-yltrimethylsilan

benzene

Pentafluoropyridine

phenyllithium