tert-butyl 2-((2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)methoxy)acetate

Base Information

Chemical Name:tert-butyl 2-((2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)methoxy)acetate
CAS No.:1242850-21-0
Molecular Formula:C₂₃H₃₂N₂O₆S
Molecular Weight:464.583
Hs Code.:

Synonyms:tert-butyl 2-((2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)methoxy)acetate

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Chemical Property of tert-butyl 2-((2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)methoxy)acetate

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Technology Process of tert-butyl 2-((2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)methoxy)acetate

There total 6 articles about tert-butyl 2-((2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)methoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 1242850-19-6
(2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)methanol

: 1242850-21-0
tert-butyl 2-((2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)methoxy)acetate

Guidance literature:: With tetrabutyl-ammonium chloride; potassium hydroxide; In water; toluene; at 20 ℃; Product distribution / selectivity;

Reference yield:

: 73627-16-4
N-[2-(1H-pyrrol-1-yl)ethyl]acetamide

: 1242850-21-0
tert-butyl 2-((2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)methoxy)acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydroxide / water / 24 h / Reflux

2.1: triethylamine / dichloromethane / 0 - 5 °C / Inert atmosphere

3.1: trifluoroacetic acid / 0 - 20 °C / Inert atmosphere

3.2: pH > 7

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

4.2: 0 °C

5.1: triethylamine / dichloromethane / 0 - 20 °C

6.1: tetrabutyl-ammonium chloride; potassium hydroxide / toluene; water / 20 °C

With lithium aluminium tetrahydride; tetrabutyl-ammonium chloride; triethylamine; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; dichloromethane; water; toluene;

Reference yield:

: 29709-35-1
1-(2-aminoethyl)pyrrole

: 1242850-21-0
tert-butyl 2-((2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl)methoxy)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 0 - 5 °C / Inert atmosphere

2.1: trifluoroacetic acid / 0 - 20 °C / Inert atmosphere

2.2: pH > 7

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

3.2: 0 °C

4.1: triethylamine / dichloromethane / 0 - 20 °C

5.1: tetrabutyl-ammonium chloride; potassium hydroxide / toluene; water / 20 °C

With lithium aluminium tetrahydride; tetrabutyl-ammonium chloride; triethylamine; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; dichloromethane; water; toluene;