2-(cyclohexylmethyl)-N-{2-[(2S)-1-methylpyrrolidin-2-yl]ethyl}-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide

Base Information

Chemical Name:2-(cyclohexylmethyl)-N-{2-[(2S)-1-methylpyrrolidin-2-yl]ethyl}-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide
CAS No.:1259499-69-8
Molecular Formula:C₂₃H₃₇N₃O₂S
Molecular Weight:419.632
Hs Code.:

Synonyms:2-(cyclohexylmethyl)-N-{2-[(2S)-1-methylpyrrolidin-2-yl]ethyl}-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide

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Chemical Property of 2-(cyclohexylmethyl)-N-{2-[(2S)-1-methylpyrrolidin-2-yl]ethyl}-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide

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Technology Process of 2-(cyclohexylmethyl)-N-{2-[(2S)-1-methylpyrrolidin-2-yl]ethyl}-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide

There total 6 articles about 2-(cyclohexylmethyl)-N-{2-[(2S)-1-methylpyrrolidin-2-yl]ethyl}-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 422545-95-7,422545-96-8
(S)-2-(1-methylpyrrolidin-2-yl)ethan-1-amine

: 1332848-74-4
2-(cyclohexylmethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chloride hydrochloride

: 1259499-69-8
2-(cyclohexylmethyl)-N-{2-[(2S)-1-methylpyrrolidin-2-yl]ethyl}-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide

Guidance literature:: (S)-2-(1-methylpyrrolidin-2-yl)ethan-1-amine; 2-(cyclohexylmethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chloride hydrochloride; In dichloromethane; at 5 - 25 ℃; for 4h;

With potassium carbonate; In water; ethyl acetate; for 0.5h;

Reference yield:

: 51387-90-7,422545-96-8
2-(2-AMINOETHYL)-1-METHYLPYRROLIDINE

: 1259499-69-8
2-(cyclohexylmethyl)-N-{2-[(2S)-1-methylpyrrolidin-2-yl]ethyl}-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol; water / 0.5 h / 65 °C / Inert atmosphere; Industry scale

2.1: hydrogenchloride / water; tert-butyl methyl ether / 0.75 h

2.2: 1.17 h

3.1: dichloromethane / 4 h / 5 - 25 °C

3.2: 0.5 h

With hydrogenchloride; In ethanol; dichloromethane; tert-butyl methyl ether; water;

Reference yield:

: 2043-61-0
cyclohexanecarbaldehyde

: 1259499-69-8
2-(cyclohexylmethyl)-N-{2-[(2S)-1-methylpyrrolidin-2-yl]ethyl}-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tris(acetoxy)borohydride / tert-butyl methyl ether / 2.5 h / 8.8 - 21.1 °C / Industry scale

1.2: 0.5 h / 20 °C / Industry scale

1.3: 20 °C / Industry scale

2.1: chlorosulfonic acid / dichloromethane / -1.8 - 35 °C / Industry scale

3.1: dichloromethane / 4 h / 5 - 25 °C

3.2: 0.5 h

With chlorosulfonic acid; sodium tris(acetoxy)borohydride; In dichloromethane; tert-butyl methyl ether;