tert-butyl 2-cyclohexyl-2-oxoethyl-(5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-yl)carbamate

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Chemical Name:tert-butyl 2-cyclohexyl-2-oxoethyl-(5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-yl)carbamate
CAS No.:1201187-50-9
Molecular Formula:C₂₆H₃₂N₄O₅S
Molecular Weight:512.63
Hs Code.:

Synonyms:tert-butyl 2-cyclohexyl-2-oxoethyl-(5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-yl)carbamate

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Chemical Property of tert-butyl 2-cyclohexyl-2-oxoethyl-(5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-yl)carbamate

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Technology Process of tert-butyl 2-cyclohexyl-2-oxoethyl-(5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-yl)carbamate

There total 3 articles about tert-butyl 2-cyclohexyl-2-oxoethyl-(5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1201187-44-1
N-(5-(p-toluenesulfonyl)pyrrolo[2,3-b]pyrazin-2-yl)carbamic acid tert-butyl ester

: 56077-28-2
Bromomethyl cyclohexyl ketone

: 1201187-50-9
tert-butyl 2-cyclohexyl-2-oxoethyl-(5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-yl)carbamate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1h;
DOI:10.1016/j.bmcl.2012.11.108

Reference yield:

: 875781-41-2
5-bromo-3-((trimethylsilyl)ethynyl)pyrazine-2-amine

: 1201187-50-9
tert-butyl 2-cyclohexyl-2-oxoethyl-(5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 - 20 °C

2: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium carbonate / 1,4-dioxane; tert-Amyl alcohol / 3 h / 95 °C

3: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

With palladium diacetate; sodium hydride; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; tert-Amyl alcohol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.11.108

Reference yield:

: 1201186-54-0
2-bromo-5-(p-toluenesulfonyl)-5H-pyrrolo[2,3-b]pyrazine

: 1201187-50-9
tert-butyl 2-cyclohexyl-2-oxoethyl-(5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium carbonate / 1,4-dioxane; tert-Amyl alcohol / 3 h / 95 °C

2: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C

With palladium diacetate; sodium hydride; potassium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; tert-Amyl alcohol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.11.108