3β-[bis(butoxycarbonyl)methyl]-3α-[(p-tert-butoxymethyl)phenyl]-7α,12α-bis(formyloxy)-24-nor-5β-cholan-22(23)-ene

Base Information

Chemical Name:3β-[bis(butoxycarbonyl)methyl]-3α-[(p-tert-butoxymethyl)phenyl]-7α,12α-bis(formyloxy)-24-nor-5β-cholan-22(23)-ene
CAS No.:198016-07-8
Molecular Formula:C₄₇H₇₀O₉
Molecular Weight:779.067
Hs Code.:

Synonyms:3β-[bis(butoxycarbonyl)methyl]-3α-[(p-tert-butoxymethyl)phenyl]-7α,12α-bis(formyloxy)-24-nor-5β-cholan-22(23)-ene

Suppliers and Price of 3β-[bis(butoxycarbonyl)methyl]-3α-[(p-tert-butoxymethyl)phenyl]-7α,12α-bis(formyloxy)-24-nor-5β-cholan-22(23)-ene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3β-[bis(butoxycarbonyl)methyl]-3α-[(p-tert-butoxymethyl)phenyl]-7α,12α-bis(formyloxy)-24-nor-5β-cholan-22(23)-ene

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3β-[bis(butoxycarbonyl)methyl]-3α-[(p-tert-butoxymethyl)phenyl]-7α,12α-bis(formyloxy)-24-nor-5β-cholan-22(23)-ene

There total 6 articles about 3β-[bis(butoxycarbonyl)methyl]-3α-[(p-tert-butoxymethyl)phenyl]-7α,12α-bis(formyloxy)-24-nor-5β-cholan-22(23)-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 22807-80-3
1-bromo-4-(tert-butoxymethyl)benzene

: 169894-18-2
2-[(5S,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-Diformyloxy-10,13-dimethyl-17-((R)-1-methyl-allyl)-hexadecahydro-cyclopenta[a]phenanthren-3-ylidene]-malonic acid dibutyl ester

: 3β-[bis(butoxycarbonyl)methyl]-3α-[(p-tert-butoxymethyl)phenyl]-7α-formyloxy-12α-hydroxy-24-nor-5β-cholan-22(23)-ene

: 198016-07-8
3β-[bis(butoxycarbonyl)methyl]-3α-[(p-tert-butoxymethyl)phenyl]-7α,12α-bis(formyloxy)-24-nor-5β-cholan-22(23)-ene

Guidance literature:: 1-bromo-4-(tert-butoxymethyl)benzene; With magnesium; In tetrahydrofuran; for 1h; sonication;

In tetrahydrofuran; at -10 - 0 ℃;

2-[(5S,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-Diformyloxy-10,13-dimethyl-17-((R)-1-methyl-allyl)-hexadecahydro-cyclopenta[a]phenanthren-3-ylidene]-malonic acid dibutyl ester; In tetrahydrofuran; at -60 - 20 ℃;
DOI:10.1021/jo971272w

Reference yield:

: 81-25-4
cholic acid

: 198016-07-8
3β-[bis(butoxycarbonyl)methyl]-3α-[(p-tert-butoxymethyl)phenyl]-7α,12α-bis(formyloxy)-24-nor-5β-cholan-22(23)-ene

Guidance literature:: Multi-step reaction with 6 steps

1.1: 92 percent / HClO₄; Ac₂O

2.1: 76 percent / cupric acetate monohydrate; pyridine; lead tetraacetate / benzene / 4 h / 40 - 90 °C

3.1: 97.8 percent / sodium acetate trihydrate / methanol / 96 h

4.1: 0.035 g / silica gel; pyridinium chlorochromate / CH₂Cl₂ / 2 h

5.1: 70 percent / SbBu₃ / tetrahydrofuran / 60 - 65 °C

6.1: magnesium / tetrahydrofuran / 1 h / sonication

6.2: CuCN / tetrahydrofuran / -10 - 0 °C

6.3: 70 percent / tetrahydrofuran / -60 - 20 °C

With pyridine; lead(IV) acetate; perchloric acid; copper diacetate; sodium acetate; acetic anhydride; silica gel; tributylstibine; magnesium; pyridinium chlorochromate; In tetrahydrofuran; methanol; dichloromethane; benzene; 1.1: Esterification / 2.1: Decarboxylation / 3.1: deformylation / 4.1: Oxidation / 5.1: Condensation / 6.1: Metallation / 6.2: transmetallation / 6.3: Addition;
DOI:10.1021/jo971272w

Reference yield:

: 2097-89-4
cholic acid triformate

: 198016-07-8
3β-[bis(butoxycarbonyl)methyl]-3α-[(p-tert-butoxymethyl)phenyl]-7α,12α-bis(formyloxy)-24-nor-5β-cholan-22(23)-ene

Guidance literature:: Multi-step reaction with 5 steps

1.1: 76 percent / cupric acetate monohydrate; pyridine; lead tetraacetate / benzene / 4 h / 40 - 90 °C

2.1: 97.8 percent / sodium acetate trihydrate / methanol / 96 h

3.1: 0.035 g / silica gel; pyridinium chlorochromate / CH₂Cl₂ / 2 h

4.1: 70 percent / SbBu₃ / tetrahydrofuran / 60 - 65 °C

5.1: magnesium / tetrahydrofuran / 1 h / sonication

5.2: CuCN / tetrahydrofuran / -10 - 0 °C

5.3: 70 percent / tetrahydrofuran / -60 - 20 °C

With pyridine; lead(IV) acetate; copper diacetate; sodium acetate; silica gel; tributylstibine; magnesium; pyridinium chlorochromate; In tetrahydrofuran; methanol; dichloromethane; benzene; 1.1: Decarboxylation / 2.1: deformylation / 3.1: Oxidation / 4.1: Condensation / 5.1: Metallation / 5.2: transmetallation / 5.3: Addition;
DOI:10.1021/jo971272w