(3alpha,5beta,7alpha,12alpha)-3,7,12-Tris(formyloxy)cholan-24-oic acid

Base Information

• Chemical Name: (3alpha,5beta,7alpha,12alpha)-3,7,12-Tris(formyloxy)cholan-24-oic acid
• CAS No.: 2097-89-4
• Molecular Formula: C27H40O8
• Molecular Weight: 492.61
• Mol file: 2097-89-4.mol

Synonyms:Tri-O-formylcholic Acid;OHJFKWAMNYLNEV-OCCHXLOTSA-N;3a,7a,12a-tri(forMyloxy)-5b-cholanic acid;3α,7α,12α-tri(formyloxy)-5β-cholan-24-oic acid;3α,7α,12α-tri(forMyloxy)-5β-cholan-24-oic acid;(3α,5β,7α,12α)-3,7,12-Tris(forMyloxy)cholan-24-oic acid;Cholan-24-oic acid, 3,7,12-tris(formyloxy)-, (3α,5β,7α,12α)-;(3alpha,5beta,7alpha,12alpha)-3,7,12-Tris(formyloxy)cholan-24-oic acid

Chemical Property of (3alpha,5beta,7alpha,12alpha)-3,7,12-Tris(formyloxy)cholan-24-oic acid

Chemical Property:

• Density: 1.21
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

3α,7α,12α-Triformyloxy-5β-cholan-24-oicAcid ≥95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Tri-O-formylcholic Acid is an intermediate used in the synthesis of 3α,7α,12α-Trihydroxycoprostanic Acid-d3 (T795157), which is a labelled analogue of 3α,7α,12α-Trihydroxycoprostanic Acid (T795155), a precursor of Cholic Acid (C432600), it undergoes side chain oxidation during the synthesis of bile acids. It was found that Zellweger’s syndrome patients have abnormal mitochondrial structure, the organelle that is responsible for the side chain oxidation, and as a consequence, excess amounts of 3α,7α,12α-Trihydroxycoprostanic Acid.

Technology Process of (3alpha,5beta,7alpha,12alpha)-3,7,12-Tris(formyloxy)cholan-24-oic acid

There total 6 articles about (3alpha,5beta,7alpha,12alpha)-3,7,12-Tris(formyloxy)cholan-24-oic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

formic acid (64-18-6) + cholic acid (81-25-4) → cholic acid triformate (2097-89-4)

Guidance literature:

at 60 ℃; for 4h;

DOI:10.1071/CH17220

Reference yield: 94.0%

formic acid (64-18-6) + cholic acid (81-25-4) + acetic anhydride (108-24-7) → cholic acid triformate (2097-89-4)

Guidance literature:

formic acid; cholic acid; With perchloric acid; at 60 - 65 ℃; for 3h;

acetic anhydride; at 40 - 50 ℃; Further stages.;

DOI:10.1039/b602415g

Reference yield:

cholic acid (81-25-4) → cholic acid triformate (2097-89-4)

Guidance literature:

In formic acid; benzene;

upstream raw materials:

formic acid

cholic acid

acetic anhydride

formaldehyd

Downstream raw materials:

3α-hydroxy-7α,12α-diformyloxy-5β-cholan-24-oic acid

N benzyl(3α,5β,7α,12α)3,7,12-trihydroxy-cholan-24-amine

N benzyl (3α,5β,7α,12α)3,7,12-trihydroxy-cholan-24-amide

sodium 5β-petromyzonol-24-sulfate