methyl 3-((7-(2,4-dimethylpyrimidin-5-yl)-3-sulfamoylquinolin-4-yl)amino)-5-isopropoxybenzoate

Base Information

• Chemical Name: methyl 3-((7-(2,4-dimethylpyrimidin-5-yl)-3-sulfamoylquinolin-4-yl)amino)-5-isopropoxybenzoate
• CAS No.: 1445790-91-9
• Molecular Formula: C₂₆H₂₇N₅O₅S
• Molecular Weight: 521.597
• Mol file: 1445790-91-9.mol

Synonyms:methyl 3-((7-(2,4-dimethylpyrimidin-5-yl)-3-sulfamoylquinolin-4-yl)amino)-5-isopropoxybenzoate

Chemical Property of methyl 3-((7-(2,4-dimethylpyrimidin-5-yl)-3-sulfamoylquinolin-4-yl)amino)-5-isopropoxybenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-((7-(2,4-dimethylpyrimidin-5-yl)-3-sulfamoylquinolin-4-yl)amino)-5-isopropoxybenzoate

There total 9 articles about methyl 3-((7-(2,4-dimethylpyrimidin-5-yl)-3-sulfamoylquinolin-4-yl)amino)-5-isopropoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 3-hydroxy-5-nitrobenzoate (55076-32-9) → methyl 3-((7-(2,4-dimethylpyrimidin-5-yl)-3-sulfamoylquinolin-4-yl)amino)-5-isopropoxybenzoate (1445790-91-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 2.5 h / 120 °C

2.1: hydrogen; palladium 10% on activated carbon / ethanol / 16 h / 20 °C

3.1: acetic acid / 3 h / 20 °C

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bis(pinacol)diborane; potassium carbonate / 1,4-dioxane / 0.5 h / 110 °C / Inert atmosphere; Microwave irradiation

4.2: 0.5 h / 110 °C / Inert atmosphere; Microwave irradiation

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; hydrogen; potassium carbonate; caesium carbonate; acetic acid; bis(pinacol)diborane; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;

Reference yield:

5-bromo-4-chloro-2,6-dimethylpyrimidine (69696-35-1) → methyl 3-((7-(2,4-dimethylpyrimidin-5-yl)-3-sulfamoylquinolin-4-yl)amino)-5-isopropoxybenzoate (1445790-91-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: toluene-4-sulfonic acid hydrazide / chloroform / 16 h / 90 °C

1.2: 1.5 h / 90 °C

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bis(pinacol)diborane; potassium carbonate / 1,4-dioxane / 0.5 h / 110 °C / Inert atmosphere; Microwave irradiation

2.2: 0.5 h / 110 °C / Inert atmosphere; Microwave irradiation

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; toluene-4-sulfonic acid hydrazide; bis(pinacol)diborane; In 1,4-dioxane; chloroform;

Reference yield:

4-hydroxy 2,6-dimethylpyrimidine (6622-92-0) → methyl 3-((7-(2,4-dimethylpyrimidin-5-yl)-3-sulfamoylquinolin-4-yl)amino)-5-isopropoxybenzoate (1445790-91-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: bromine / 1,4-dioxane / 0.75 h / 20 °C

2.1: trichlorophosphate / 3 h / 110 °C

3.1: toluene-4-sulfonic acid hydrazide / chloroform / 16 h / 90 °C

3.2: 1.5 h / 90 °C

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bis(pinacol)diborane; potassium carbonate / 1,4-dioxane / 0.5 h / 110 °C / Inert atmosphere; Microwave irradiation

4.2: 0.5 h / 110 °C / Inert atmosphere; Microwave irradiation

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; bromine; potassium carbonate; toluene-4-sulfonic acid hydrazide; bis(pinacol)diborane; trichlorophosphate; In 1,4-dioxane; chloroform;

upstream raw materials:

5-bromo-2,6-dimethylpyrimidin-4-ol

4-hydroxy 2,6-dimethylpyrimidine

5-bromo-4-chloro-2,6-dimethylpyrimidine

methyl 3-[(1-methylethyl)oxy]-5-nitrobenzoate

Downstream raw materials:

3-((7-(2,4-dimethylpyrimidin-5-yl)-3-sulfamoylquinolin-4-yl)amino)-5-isopropoxybenzoic acid