4-[3-[1,3]-dioxolan-2-yl-1-(4-fluorophenyl)-1-hydroxypropyl]-3-hydroxymethylbenzonitrile

Base Information

Chemical Name:4-[3-[1,3]-dioxolan-2-yl-1-(4-fluorophenyl)-1-hydroxypropyl]-3-hydroxymethylbenzonitrile
CAS No.:526204-34-2
Molecular Formula:C₂₀H₂₀FNO₄
Molecular Weight:357.382
Hs Code.:

Synonyms:4-[3-[1,3]-dioxolan-2-yl-1-(4-fluorophenyl)-1-hydroxypropyl]-3-hydroxymethylbenzonitrile

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Chemical Property of 4-[3-[1,3]-dioxolan-2-yl-1-(4-fluorophenyl)-1-hydroxypropyl]-3-hydroxymethylbenzonitrile

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Technology Process of 4-[3-[1,3]-dioxolan-2-yl-1-(4-fluorophenyl)-1-hydroxypropyl]-3-hydroxymethylbenzonitrile

There total 1 articles about 4-[3-[1,3]-dioxolan-2-yl-1-(4-fluorophenyl)-1-hydroxypropyl]-3-hydroxymethylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 82104-74-3
1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile

: 37610-80-3
1,3-dioxolan-2-ylethylmagnesium bromide

: 352-13-6
4-flourophenylmagnesium bromide

: 526204-34-2
4-[3-[1,3]-dioxolan-2-yl-1-(4-fluorophenyl)-1-hydroxypropyl]-3-hydroxymethylbenzonitrile

Guidance literature:: 1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile; 4-flourophenylmagnesium bromide; In tetrahydrofuran; diethyl ether; at 5 - 20 ℃; for 5h;

1,3-dioxolan-2-ylethylmagnesium bromide; In tetrahydrofuran; diethyl ether; at 20 ℃; for 14h;

With water; ammonium chloride; at 0 ℃;

Reference yield:

: 526204-34-2
4-[3-[1,3]-dioxolan-2-yl-1-(4-fluorophenyl)-1-hydroxypropyl]-3-hydroxymethylbenzonitrile

: 345663-54-9
1-(2-[1,3]-dioxolan-2-yl-ethyl)-1-(4-fluorophenyl)-1,3-dihydro-isobenzofuran-5-carbonitrile

Guidance literature:: 4-[3-[1,3]-dioxolan-2-yl-1-(4-fluorophenyl)-1-hydroxypropyl]-3-hydroxymethylbenzonitrile; With triethylamine; In dichloromethane; at 20 ℃; for 0.0833333h;

With methanesulfonyl chloride; In dichloromethane; at 5 - 20 ℃; for 0.166667h;