Technology Process of 4-(3-amino-4-fluorophenoxy)-N-methylpyrimidin-2-amine trifluoroacetate
There total 6 articles about 4-(3-amino-4-fluorophenoxy)-N-methylpyrimidin-2-amine trifluoroacetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium tert-butylate / N,N-dimethyl acetamide / 50 °C
2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C
2.2: 40 °C
With
potassium tert-butylate; 3-chloro-benzenecarboperoxoic acid;
In
dichloromethane; N,N-dimethyl acetamide;
- Guidance literature:
-
2-fluoro-5-(2-(methylthio)pyrimidin-4-yloxy)benzenamine;
With
3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
at 20 ℃;
methylamine;
In
tetrahydrofuran;
at 40 ℃;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydroxide / water / -10 °C
2.1: sulfuric acid; 2-methyl-5-nitrophenol / 0.5 h / 0 °C
3.1: sodium hydroxide; water / 4 h / Reflux
4.1: hydrogen; palladium 10% on activated carbon / ethanol / 12 h / 2585.81 Torr
5.1: potassium tert-butylate / N,N-dimethyl acetamide / 50 °C
6.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C
6.2: 40 °C
With
2-methyl-5-nitrophenol; sulfuric acid; palladium 10% on activated carbon; potassium tert-butylate; water; hydrogen; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide;
In
ethanol; dichloromethane; N,N-dimethyl acetamide; water;