TREN-1-Me-3,2-HOPO-TAM-Triazolide, benzyl protected

Base Information

• Chemical Name: TREN-1-Me-3,2-HOPO-TAM-Triazolide, benzyl protected
• CAS No.: 830327-50-9
• Molecular Formula: C₅₉H₅₉N₇O₁₀S₂
• Molecular Weight: 1090.29
• Mol file: 830327-50-9.mol

Synonyms:TREN-1-Me-3,2-HOPO-TAM-Triazolide, benzyl protected

Chemical Property of TREN-1-Me-3,2-HOPO-TAM-Triazolide, benzyl protected

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of TREN-1-Me-3,2-HOPO-TAM-Triazolide, benzyl protected

There total 2 articles about TREN-1-Me-3,2-HOPO-TAM-Triazolide, benzyl protected which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(2,3-bis(benzyloxy)-1,4-phenylene)bis((2-thioxothiazolidin-3-yl)methanone) (492454-84-9) + N,N-Bis(3-benzyloxy-1-methyl-2-oxo-1,2-dihydropyridin-4-yl)carboxamido-ethyl-N-(2-aminoethyl)amine (Bn-TREN-Bis-Me-3,2-HOPO) (186834-28-6) → TREN-1-Me-3,2-HOPO-TAM-Triazolide, benzyl protected (830327-50-9)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 15h;

DOI:10.1021/ja057805x

Reference yield:

2,3-bis(benzyloxy)-terephthalic acid (131933-37-4) → TREN-1-Me-3,2-HOPO-TAM-Triazolide, benzyl protected (830327-50-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 24 h

1.2: 2 h / -35 °C

2.1: dichloromethane / 9 h

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; toluene;

Reference yield: 95.3%

TREN-1-Me-3,2-HOPO-TAM-Triazolide, benzyl protected (830327-50-9) + {2-[(2-amino-ethyl)-(2-tert-butoxycarbonylamino-ethyl)-amino]-ethyl}-carbamic acid tert-butyl ester (161038-11-5) → {2-[(2-{2,3-bis-benzyloxy-4-[2-(bis-{2-[(3-benzyloxy-1-methyl-2-oxo-1,2-dihydro-pyridine-4-carbonyl)-amino]-ethyl}-amino)-ethylcarbamoyl]-benzoylamino}-ethyl)-(2-tert-butoxycarbonylamino-ethyl)-amino]-ethyl}-carbamic acid tert-butyl ester (888330-76-5)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1021/ja057805x

upstream raw materials:

(2,3-bis(benzyloxy)-1,4-phenylene)bis((2-thioxothiazolidin-3-yl)methanone)

N,N-Bis(3-benzyloxy-1-methyl-2-oxo-1,2-dihydropyridin-4-yl)carboxamido-ethyl-N-(2-aminoethyl)amine (Bn-TREN-Bis-Me-3,2-HOPO)

2,3-bis(benzyloxy)-terephthalic acid

Downstream raw materials:

{2-[(2-{2,3-bis-benzyloxy-4-[2-(bis-{2-[(3-benzyloxy-1-methyl-2-oxo-1,2-dihydro-pyridine-4-carbonyl)-amino]-ethyl}-amino)-ethylcarbamoyl]-benzoylamino}-ethyl)-(2-tert-butoxycarbonylamino-ethyl)-amino]-ethyl}-carbamic acid tert-butyl ester

[2-(2-{2,3-bis-benzyloxy-4-[2-(bis-{2-[(3-benzyloxy-1-methyl-2-oxo-1,2-dihydro-pyridine-4-carbonyl)-amino]-ethyl}-amino)-ethylcarbamoyl]-benzoylamino}-ethylamino)-ethyl]-carbamic acid tert-butyl ester

TREN-1-Me-3,2-HOPO-TAM-O₂-NH₂, benzyl protected

TREN-1-Me-3,2-HOPO-TAM-DME