4-Pyridinecarboxamide, N,N'-[[(2-aminoethyl)imino]di-2,1-ethanediyl]bis[1,2-dihydro-1-methyl-2- oxo-3-(phenylmethoxy)-

Base Information

• Chemical Name: 4-Pyridinecarboxamide, N,N'-[[(2-aminoethyl)imino]di-2,1-ethanediyl]bis[1,2-dihydro-1-methyl-2- oxo-3-(phenylmethoxy)-
• CAS No.: 186834-28-6
• Molecular Formula: C34H40N6O6
• Molecular Weight: 628.728
• Mol file: 186834-28-6.mol

Synonyms:

Chemical Property of 4-Pyridinecarboxamide, N,N'-[[(2-aminoethyl)imino]di-2,1-ethanediyl]bis[1,2-dihydro-1-methyl-2- oxo-3-(phenylmethoxy)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Pyridinecarboxamide, N,N'-[[(2-aminoethyl)imino]di-2,1-ethanediyl]bis[1,2-dihydro-1-methyl-2- oxo-3-(phenylmethoxy)-

There total 1 articles about 4-Pyridinecarboxamide, N,N'-[[(2-aminoethyl)imino]di-2,1-ethanediyl]bis[1,2-dihydro-1-methyl-2- oxo-3-(phenylmethoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

2,2',2''-triaminotriethylamine (4097-89-6) + 3-(benzyloxy)-1-methyl-4-<(2-thioxothiazoldin-1-yl)carbonyl>-2(1H)-pyridinone (169237-39-2) → N,N-Bis(3-benzyloxy-1-methyl-2-oxo-1,2-dihydropyridin-4-yl)carboxamido-ethyl-N-(2-aminoethyl)amine (Bn-TREN-Bis-Me-3,2-HOPO) (186834-28-6)

Guidance literature:

In dichloromethane; for 16h;

Reference yield: 95.0%

(2,3-bis(benzyloxy)-1,4-phenylene)bis((2-thioxothiazolidin-3-yl)methanone) (492454-84-9) + N,N-Bis(3-benzyloxy-1-methyl-2-oxo-1,2-dihydropyridin-4-yl)carboxamido-ethyl-N-(2-aminoethyl)amine (Bn-TREN-Bis-Me-3,2-HOPO) (186834-28-6) → TREN-1-Me-3,2-HOPO-TAM-Triazolide, benzyl protected (830327-50-9)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 15h;

DOI:10.1021/ja057805x

Reference yield: 91.0%

C38H29F5N2O7 (1332701-98-0) + N,N-Bis(3-benzyloxy-1-methyl-2-oxo-1,2-dihydropyridin-4-yl)carboxamido-ethyl-N-(2-aminoethyl)amine (Bn-TREN-Bis-Me-3,2-HOPO) (186834-28-6) → C66H68N8O12 (1332702-06-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 15h;

DOI:10.1021/ja204516p

upstream raw materials:

2,2',2''-triaminotriethylamine

3-(benzyloxy)-1-methyl-4-<(2-thioxothiazoldin-1-yl)carbonyl>-2(1H)-pyridinone

Downstream raw materials:

TREN-1-Me-3,2-HOPO-TAM-Triazolide, benzyl protected

(2-{2,3-bis-benzyloxy-4-[2-(bis-{2-[(3-benzyloxy-1-methyl-2-oxo-1,2-dihydro-pyridine-4-carbonyl)-amino]-ethyl}-amino)-ethylcarbamoyl]-benzoylamino}-ethyl)-carbamic acid tert-butyl ester

[2-(2-{2,3-bis-benzyloxy-4-[2-(bis-{2-[(3-benzyloxy-1-methyl-2-oxo-1,2-dihydro-pyridine-4-carbonyl)-amino]-ethyl}-amino)-ethylcarbamoyl]-benzoylamino}-ethylamino)-ethyl]-carbamic acid tert-butyl ester

{2-[(2-{2,3-bis-benzyloxy-4-[2-(bis-{2-[(3-benzyloxy-1-methyl-2-oxo-1,2-dihydro-pyridine-4-carbonyl)-amino]-ethyl}-amino)-ethylcarbamoyl]-benzoylamino}-ethyl)-(2-tert-butoxycarbonylamino-ethyl)-amino]-ethyl}-carbamic acid tert-butyl ester