3-(3-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]anilino}propyl)benzonitrile

Base Information

Chemical Name:3-(3-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]anilino}propyl)benzonitrile
CAS No.:454437-24-2
Molecular Formula:C₂₆H₃₃N₃O₃
Molecular Weight:435.566
Hs Code.:

Synonyms:3-(3-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]anilino}propyl)benzonitrile

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Chemical Property of 3-(3-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]anilino}propyl)benzonitrile

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Technology Process of 3-(3-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]anilino}propyl)benzonitrile

There total 7 articles about 3-(3-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]anilino}propyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 337519-98-9
3-((E)-3-{4-[1-(t-butoxycarbonyl)piperidin-4-yloxy]phenylamino}-1-propenyl)benzonitrile

: 454437-24-2
3-(3-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]anilino}propyl)benzonitrile

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 1h;
DOI:10.1016/S0968-0896(01)00418-7

Reference yield:

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 454437-24-2
3-(3-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]anilino}propyl)benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 77 percent / Ph₃P; DEAD / tetrahydrofuran / 21 h / 20 °C

2: 98 percent / H₂ / 10 percent Pd/C / ethanol / 15 h / 20 °C

3: 59 percent / NaB(OAc)3H / CH₂Cl₂; acetic acid / 0.75 h / 20 °C

4: 62 percent / H₂ / 10 percent Pd/C / ethanol / 1 h / 20 °C

With hydrogen; sodium tris(acetoxy)borohydride; triphenylphosphine; diethylazodicarboxylate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; acetic acid; 1: Mitsunobu condensation;
DOI:10.1016/S0968-0896(01)00418-7

Reference yield:

: 24964-64-5
3-Cyanobenzaldehyde

: 454437-24-2
3-(3-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]anilino}propyl)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / benzene / 35 h / Heating

2: 59 percent / NaB(OAc)3H / CH₂Cl₂; acetic acid / 0.75 h / 20 °C

3: 62 percent / H₂ / 10 percent Pd/C / ethanol / 1 h / 20 °C

With hydrogen; sodium tris(acetoxy)borohydride; palladium on activated charcoal; In ethanol; dichloromethane; acetic acid; benzene;
DOI:10.1016/S0968-0896(01)00418-7