3-((E)-3-{4-[1-(t-butoxycarbonyl)piperidin-4-yloxy]phenylamino}-1-propenyl)benzonitrile

Base Information

Chemical Name:3-((E)-3-{4-[1-(t-butoxycarbonyl)piperidin-4-yloxy]phenylamino}-1-propenyl)benzonitrile
CAS No.:337519-98-9
Molecular Formula:C₂₆H₃₁N₃O₃
Molecular Weight:433.55
Hs Code.:

Synonyms:3-((E)-3-{4-[1-(t-butoxycarbonyl)piperidin-4-yloxy]phenylamino}-1-propenyl)benzonitrile

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Chemical Property of 3-((E)-3-{4-[1-(t-butoxycarbonyl)piperidin-4-yloxy]phenylamino}-1-propenyl)benzonitrile

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Technology Process of 3-((E)-3-{4-[1-(t-butoxycarbonyl)piperidin-4-yloxy]phenylamino}-1-propenyl)benzonitrile

There total 8 articles about 3-((E)-3-{4-[1-(t-butoxycarbonyl)piperidin-4-yloxy]phenylamino}-1-propenyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 141-78-6
ethyl acetate

: 98116-49-5
3-cyano-1-(2-formylethenyl)benzene

: 138227-63-1
tert-butyl 4-(4-aminophenoxy)piperidine-1-carboxylate

: 337519-98-9
3-((E)-3-{4-[1-(t-butoxycarbonyl)piperidin-4-yloxy]phenylamino}-1-propenyl)benzonitrile

Guidance literature:: With sodium borohydrid; cerium chloride; silica gel; In ethanol; hexane; toluene;

Reference yield: 59.0%

: 98116-49-5
3-cyano-1-(2-formylethenyl)benzene

: 138227-63-1
tert-butyl 4-(4-aminophenoxy)piperidine-1-carboxylate

: 337519-98-9
3-((E)-3-{4-[1-(t-butoxycarbonyl)piperidin-4-yloxy]phenylamino}-1-propenyl)benzonitrile

Guidance literature:: With sodium tris(acetoxy)borohydride; In dichloromethane; acetic acid; at 20 ℃; for 0.75h;
DOI:10.1016/S0968-0896(01)00418-7

Reference yield:

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 337519-98-9
3-((E)-3-{4-[1-(t-butoxycarbonyl)piperidin-4-yloxy]phenylamino}-1-propenyl)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: DEAD; PPh₃

2: NaCNBH₃

With sodium cyanoborohydride; triphenylphosphine; diethylazodicarboxylate; 1: Mitsunobu reaction;
DOI:10.1016/S0960-894X(02)00142-7