(E)-2,3-dihydro-2-<(ethoxycarbonyl)methylene>-1-methyl-5-phenyl-1H-1,4-benzodiazepine

Base Information

• Chemical Name: (E)-2,3-dihydro-2-<(ethoxycarbonyl)methylene>-1-methyl-5-phenyl-1H-1,4-benzodiazepine
• CAS No.: 174311-62-7
• Molecular Formula: C₂₀H₂₀N₂O₂
• Molecular Weight: 320.391
• Mol file: 174311-62-7.mol

Synonyms:(E)-2,3-dihydro-2-<(ethoxycarbonyl)methylene>-1-methyl-5-phenyl-1H-1,4-benzodiazepine

Chemical Property of (E)-2,3-dihydro-2-<(ethoxycarbonyl)methylene>-1-methyl-5-phenyl-1H-1,4-benzodiazepine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2,3-dihydro-2-<(ethoxycarbonyl)methylene>-1-methyl-5-phenyl-1H-1,4-benzodiazepine

There total 2 articles about (E)-2,3-dihydro-2-<(ethoxycarbonyl)methylene>-1-methyl-5-phenyl-1H-1,4-benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

methyl p-toluene sulfonate (80-48-8) + (Z)-2,3-dihydro-2-<(ethoxycarbonyl)methylene>-5-phenyl-1H-1,4-benzodiazepine (174311-61-6) → (E)-2,3-dihydro-2-<(ethoxycarbonyl)methylene>-1-methyl-5-phenyl-1H-1,4-benzodiazepine (174311-62-7)

Guidance literature:

With sodium hydroxide; tetrabutylammomium bromide; In benzene; for 1.5h; Heating;

DOI:10.1021/jm950423p

Reference yield:

2,3-dihydro-2-<(ethoxycarbonyl)methylene>-5-phenyl-1H-1,4-benzodiazepine 4-oxide → (E)-2,3-dihydro-2-<(ethoxycarbonyl)methylene>-1-methyl-5-phenyl-1H-1,4-benzodiazepine (174311-62-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / PCl₃ / CHCl₃ / 0.67 h / Heating

2: 68 percent / aq. 50percent NaOH, tetrabutylammonium bromide / benzene / 1.5 h / Heating

With sodium hydroxide; tetrabutylammomium bromide; phosphorus trichloride; In chloroform; benzene;

DOI:10.1021/jm950423p

Reference yield: 84.0%

(E)-2,3-dihydro-2-<(ethoxycarbonyl)methylene>-1-methyl-5-phenyl-1H-1,4-benzodiazepine (174311-62-7) → 2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepine-2-acetic acid ethyl ester (174311-63-8)

Guidance literature:

With triethylsilane; In trifluoroacetic acid; for 0.5h;

DOI:10.1021/jm950423p

upstream raw materials:

methyl p-toluene sulfonate

(Z)-2,3-dihydro-2-<(ethoxycarbonyl)methylene>-5-phenyl-1H-1,4-benzodiazepine

Downstream raw materials:

2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepine-2-acetic acid ethyl ester

2,3-dihydro-2-(2-chloroethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

2,3-dihydro-2-(2-hydroxyethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine

2,3-dihydro-2-(2-aminoethyl)-1-methyl-5-phenyl-1H-1,4-benzodiazepine