4-(4-chloro-6-Methoxy-3-nitroquinolin-7-yl)-3,5-diMethylisoxazole

Base Information

Chemical Name:4-(4-chloro-6-Methoxy-3-nitroquinolin-7-yl)-3,5-diMethylisoxazole
CAS No.:1300031-65-5
Molecular Formula:C₁₅H₁₂ClN₃O₄
Molecular Weight:333.731
Hs Code.:
Mol file:1300031-65-5.mol

Synonyms:4-chloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-6-methoxy-3-nitroquinoline

Suppliers and Price of 4-(4-chloro-6-Methoxy-3-nitroquinolin-7-yl)-3,5-diMethylisoxazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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price

Total 7 raw suppliers

Chemical Property of 4-(4-chloro-6-Methoxy-3-nitroquinolin-7-yl)-3,5-diMethylisoxazole

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 4-(4-chloro-6-Methoxy-3-nitroquinolin-7-yl)-3,5-diMethylisoxazole

There total 23 articles about 4-(4-chloro-6-Methoxy-3-nitroquinolin-7-yl)-3,5-diMethylisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1300031-66-6
7-(3,5-dimethyl-4-isoxazolyl)-6-(methyloxy)-3-nitro-4-quinolinol

: 1300031-65-5
4-chloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-6-methoxy-3-nitroquinoline

Guidance literature:: 7-(3,5-dimethyl-4-isoxazolyl)-6-(methyloxy)-3-nitro-4-quinolinol; With trichlorophosphate; Reflux;

With sodium hydrogencarbonate; In water;

Reference yield:

: 16114-47-9
3,5-dimethylisoxazole-4-boronic acid

: 1300031-65-5
4-chloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-6-methoxy-3-nitroquinoline

Guidance literature:: Multi-step reaction with 8 steps

1.1: caesium carbonate / 1,2-dimethoxyethane; water / 0.17 h / Inert atmosphere

1.2: 4 h / 90 °C / Inert atmosphere

2.1: hydrogen / 5%-palladium/activated carbon / ethyl acetate; ethanol; water / 24 h

3.1: 1 h / 130 °C

4.1: diphenylether / 0.33 h / Reflux

5.1: sodium hydroxide; water / ethanol; water / Reflux

5.2: 40 °C / pH 4

6.1: diphenylether / 0.5 h / Reflux

7.1: nitric acid; propionic acid / 1 h / 100 °C

8.1: trichlorophosphate / 3 h / 110 °C

8.2: 0.17 h

With water; hydrogen; nitric acid; caesium carbonate; propionic acid; sodium hydroxide; trichlorophosphate; 5%-palladium/activated carbon; In 1,2-dimethoxyethane; diphenylether; ethanol; water; ethyl acetate;

Reference yield:

: 74587-12-5
3-iodo-4-methoxyaniline

: 1300031-65-5
4-chloro-7-(3,5-dimethyl-1,2-oxazol-4-yl)-6-methoxy-3-nitroquinoline

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1 h / Reflux

1.2: 1 h / Reflux

2.1: diphenylether / 0.17 h / 260 °C

3.1: barium hydroxide octahydrate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 105 °C / Inert atmosphere

4.1: nitric acid; propionic acid / 1 h / 100 °C

5.1: trichlorophosphate / Reflux

With barium hydroxide octahydrate; nitric acid; propionic acid; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; diphenylether; water; 3.1: Suzuki Coupling;