2,3-dimethoxy-6-iodo-N-methyl-N-(6,7-methylenedioxy-1-naphthyl)benzamide

Base Information

• Chemical Name: 2,3-dimethoxy-6-iodo-N-methyl-N-(6,7-methylenedioxy-1-naphthyl)benzamide
• CAS No.: 181634-57-1
• Molecular Formula: C₂₁H₁₈INO₅
• Molecular Weight: 491.282
• Mol file: 181634-57-1.mol

Synonyms:2,3-dimethoxy-6-iodo-N-methyl-N-(6,7-methylenedioxy-1-naphthyl)benzamide

Chemical Property of 2,3-dimethoxy-6-iodo-N-methyl-N-(6,7-methylenedioxy-1-naphthyl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3-dimethoxy-6-iodo-N-methyl-N-(6,7-methylenedioxy-1-naphthyl)benzamide

There total 7 articles about 2,3-dimethoxy-6-iodo-N-methyl-N-(6,7-methylenedioxy-1-naphthyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

6-Iodo-2,3-dimethoxy-N-(6,7-methylenedioxy-1-naphthyl)benzamide (181634-58-2) + methyl iodide (74-88-4) → 2,3-dimethoxy-6-iodo-N-methyl-N-(6,7-methylenedioxy-1-naphthyl)benzamide (181634-57-1)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h;

DOI:10.1055/s-2001-11424

Reference yield:

6,7-bis(methylsulfonyloxy)-1-nitronaphthalene (56517-24-9) → 2,3-dimethoxy-6-iodo-N-methyl-N-(6,7-methylenedioxy-1-naphthyl)benzamide (181634-57-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 2percent aq. NaOH

2: CsF / dimethylformamide

3: H₂ / Pd/C / tetrahydrofuran

4: 1.) (COCl)2

With sodium hydroxide; oxalyl dichloride; hydrogen; cesium fluoride; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1248/cpb.44.1634

Reference yield:

5-nitro-2,3-dihydroxynaphthalene (77542-54-2) → 2,3-dimethoxy-6-iodo-N-methyl-N-(6,7-methylenedioxy-1-naphthyl)benzamide (181634-57-1)

Guidance literature:

Multi-step reaction with 4 steps

1: CsF / dimethylformamide

2: H₂ / Pd/C / tetrahydrofuran

3: 1.) (COCl)2

With oxalyl dichloride; hydrogen; cesium fluoride; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1248/cpb.44.1634

upstream raw materials:

6-Iodo-2,3-dimethoxy-N-(6,7-methylenedioxy-1-naphthyl)benzamide

methyl iodide

6-iodo-2,3-dimethoxybenzoic acid

2,3-dimethoxy-6-iodobenzoyl chloride

Downstream raw materials:

oxychelerythrine