4-((2-amino-3-(5-(benzyloxy)pyridin-2-yl)propanamido)methyl)-N-hydroxybenzamide trifluororoacetic acid

Base Information

Chemical Name:4-((2-amino-3-(5-(benzyloxy)pyridin-2-yl)propanamido)methyl)-N-hydroxybenzamide trifluororoacetic acid
CAS No.:1350618-49-3
Molecular Formula:C₂HF₃O₂*C₂₃H₂₄N₄O₄
Molecular Weight:534.492
Hs Code.:

Synonyms:4-((2-amino-3-(5-(benzyloxy)pyridin-2-yl)propanamido)methyl)-N-hydroxybenzamide trifluororoacetic acid

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Chemical Property of 4-((2-amino-3-(5-(benzyloxy)pyridin-2-yl)propanamido)methyl)-N-hydroxybenzamide trifluororoacetic acid

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Technology Process of 4-((2-amino-3-(5-(benzyloxy)pyridin-2-yl)propanamido)methyl)-N-hydroxybenzamide trifluororoacetic acid

There total 5 articles about 4-((2-amino-3-(5-(benzyloxy)pyridin-2-yl)propanamido)methyl)-N-hydroxybenzamide trifluororoacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1350618-47-1
tert-butyl 3-(5-(benzyloxy)pyridin-2-yl)-1-(4-(hydroxycarbamoyl)benzylamino)-1-oxopropan-2-ylcarbamate

: 76-05-1
trifluoroacetic acid

: 1350618-49-3
4-((2-amino-3-(5-(benzyloxy)pyridin-2-yl)propanamido)methyl)-N-hydroxybenzamide trifluororoacetic acid

Guidance literature:: In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: 18469-52-8
methyl 4-(aminomethyl)benzoate

: 1350618-49-3
4-((2-amino-3-(5-(benzyloxy)pyridin-2-yl)propanamido)methyl)-N-hydroxybenzamide trifluororoacetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 20 °C

2.1: water; lithium hydroxide / tetrahydrofuran / 4 h / 60 °C

2.2: pH 2 / Acidic conditions

3.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.5 h / 0 °C

3.2: 0.5 h / 0 - 20 °C

4.1: dichloromethane / 4 h / 20 °C

With water; chloroformic acid ethyl ester; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1350618-57-3
4-((3-(5-(benzyloxy)pyridin-2-yl)-2-(tert-butoxycarbonyl-amino)propanamido)methyl)benzoic acid

: 1350618-49-3
4-((2-amino-3-(5-(benzyloxy)pyridin-2-yl)propanamido)methyl)-N-hydroxybenzamide trifluororoacetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.5 h / 0 °C

1.2: 0.5 h / 0 - 20 °C

2.1: dichloromethane / 4 h / 20 °C

With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; dichloromethane;