tert-butyl 3-(5-(benzyloxy)pyridin-2-yl)-1-(4-(hydroxycarbamoyl)benzylamino)-1-oxopropan-2-ylcarbamate

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Chemical Name:tert-butyl 3-(5-(benzyloxy)pyridin-2-yl)-1-(4-(hydroxycarbamoyl)benzylamino)-1-oxopropan-2-ylcarbamate
CAS No.:1350618-47-1
Molecular Formula:C₂₈H₃₂N₄O₆
Molecular Weight:520.585
Hs Code.:

Synonyms:tert-butyl 3-(5-(benzyloxy)pyridin-2-yl)-1-(4-(hydroxycarbamoyl)benzylamino)-1-oxopropan-2-ylcarbamate

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Chemical Property of tert-butyl 3-(5-(benzyloxy)pyridin-2-yl)-1-(4-(hydroxycarbamoyl)benzylamino)-1-oxopropan-2-ylcarbamate

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Technology Process of tert-butyl 3-(5-(benzyloxy)pyridin-2-yl)-1-(4-(hydroxycarbamoyl)benzylamino)-1-oxopropan-2-ylcarbamate

There total 4 articles about tert-butyl 3-(5-(benzyloxy)pyridin-2-yl)-1-(4-(hydroxycarbamoyl)benzylamino)-1-oxopropan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1350618-57-3
4-((3-(5-(benzyloxy)pyridin-2-yl)-2-(tert-butoxycarbonyl-amino)propanamido)methyl)benzoic acid

: 1350618-47-1
tert-butyl 3-(5-(benzyloxy)pyridin-2-yl)-1-(4-(hydroxycarbamoyl)benzylamino)-1-oxopropan-2-ylcarbamate

Guidance literature:: 4-((3-(5-(benzyloxy)pyridin-2-yl)-2-(tert-butoxycarbonyl-amino)propanamido)methyl)benzoic acid; With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; at 0 ℃; for 0.5h;

With hydroxylamine hydrochloride; potassium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 0.5h;

Reference yield:

: 18469-52-8
methyl 4-(aminomethyl)benzoate

: 1350618-47-1
tert-butyl 3-(5-(benzyloxy)pyridin-2-yl)-1-(4-(hydroxycarbamoyl)benzylamino)-1-oxopropan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 20 °C

2.1: water; lithium hydroxide / tetrahydrofuran / 4 h / 60 °C

2.2: pH 2

3.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.5 h / 0 °C

3.2: 0.5 h / 20 °C

With water; chloroformic acid ethyl ester; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1350618-56-2
methyl 4-((3-(5-(benzyloxy)pyridin-2-yl)-2-(tert-butoxycarbonylamino)propanamido)methyl)benzoate

: 1350618-47-1
tert-butyl 3-(5-(benzyloxy)pyridin-2-yl)-1-(4-(hydroxycarbamoyl)benzylamino)-1-oxopropan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; lithium hydroxide / tetrahydrofuran / 4 h / 60 °C

1.2: pH 2

2.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.5 h / 0 °C

2.2: 0.5 h / 20 °C

With water; chloroformic acid ethyl ester; triethylamine; lithium hydroxide; In tetrahydrofuran;