methyl 4-((3-(5-(benzyloxy)pyridin-2-yl)-2-(tert-butoxycarbonylamino)propanamido)methyl)benzoate

Base Information

Chemical Name:methyl 4-((3-(5-(benzyloxy)pyridin-2-yl)-2-(tert-butoxycarbonylamino)propanamido)methyl)benzoate
CAS No.:1350618-56-2
Molecular Formula:C₂₉H₃₃N₃O₆
Molecular Weight:519.598
Hs Code.:

Synonyms:methyl 4-((3-(5-(benzyloxy)pyridin-2-yl)-2-(tert-butoxycarbonylamino)propanamido)methyl)benzoate

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Chemical Property of methyl 4-((3-(5-(benzyloxy)pyridin-2-yl)-2-(tert-butoxycarbonylamino)propanamido)methyl)benzoate

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Technology Process of methyl 4-((3-(5-(benzyloxy)pyridin-2-yl)-2-(tert-butoxycarbonylamino)propanamido)methyl)benzoate

There total 1 articles about methyl 4-((3-(5-(benzyloxy)pyridin-2-yl)-2-(tert-butoxycarbonylamino)propanamido)methyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 219638-18-3
((±)-3-(5-(benzyloxy)pyridine-2-yl)-2-(tert-butoxycarbonylamino)propanoic acid)

: 18469-52-8
methyl 4-(aminomethyl)benzoate

: 1350618-56-2
methyl 4-((3-(5-(benzyloxy)pyridin-2-yl)-2-(tert-butoxycarbonylamino)propanamido)methyl)benzoate

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 2h;

Reference yield: 55.0%

: 1350618-56-2
methyl 4-((3-(5-(benzyloxy)pyridin-2-yl)-2-(tert-butoxycarbonylamino)propanamido)methyl)benzoate

: 1350618-57-3
4-((3-(5-(benzyloxy)pyridin-2-yl)-2-(tert-butoxycarbonyl-amino)propanamido)methyl)benzoic acid

Guidance literature:: methyl 4-((3-(5-(benzyloxy)pyridin-2-yl)-2-(tert-butoxycarbonylamino)propanamido)methyl)benzoate; With water; lithium hydroxide; In tetrahydrofuran; at 60 ℃; for 4h;

In tetrahydrofuran; water; pH=2;

Reference yield:

: 1350618-56-2
methyl 4-((3-(5-(benzyloxy)pyridin-2-yl)-2-(tert-butoxycarbonylamino)propanamido)methyl)benzoate

: 1350618-51-7
4-((2-amino-3-(5-hydroxypyridin-2-yl)-propanamido) methyl)-N-hydroxybenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; lithium hydroxide / tetrahydrofuran / 4 h / 60 °C

1.2: pH 2

2.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.5 h / 0 °C

2.2: 0.5 h / 20 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 4 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

With water; hydrogen; chloroformic acid ethyl ester; triethylamine; trifluoroacetic acid; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane;