(E)-ethyl 7-(N-(prop-2-ynyl)-N-tosylamino)-4-(pivaloyloxy)hept-5-en-2-ynoate

Base Information

Chemical Name:(E)-ethyl 7-(N-(prop-2-ynyl)-N-tosylamino)-4-(pivaloyloxy)hept-5-en-2-ynoate
CAS No.:1365555-08-3
Molecular Formula:C₂₄H₂₉NO₆S
Molecular Weight:459.563
Hs Code.:

Synonyms:(E)-ethyl 7-(N-(prop-2-ynyl)-N-tosylamino)-4-(pivaloyloxy)hept-5-en-2-ynoate

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Chemical Property of (E)-ethyl 7-(N-(prop-2-ynyl)-N-tosylamino)-4-(pivaloyloxy)hept-5-en-2-ynoate

Chemical Property:

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Technology Process of (E)-ethyl 7-(N-(prop-2-ynyl)-N-tosylamino)-4-(pivaloyloxy)hept-5-en-2-ynoate

There total 4 articles about (E)-ethyl 7-(N-(prop-2-ynyl)-N-tosylamino)-4-(pivaloyloxy)hept-5-en-2-ynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1365555-62-9
C₁₉H₂₁NO₅S

: 3282-30-2
pivaloyl chloride

: 1365555-08-3
(E)-ethyl 7-(N-(prop-2-ynyl)-N-tosylamino)-4-(pivaloyloxy)hept-5-en-2-ynoate

Guidance literature:: With pyridine; dmap; In dichloromethane; at 0 ℃; Inert atmosphere;
DOI:10.1021/ja2109097

Reference yield:

: 384836-87-7
(2E)-N-(3-formyl-2-propenyl)-N-(2-propynyl)tosylamide

: 1365555-08-3
(E)-ethyl 7-(N-(prop-2-ynyl)-N-tosylamino)-4-(pivaloyloxy)hept-5-en-2-ynoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; hexanes / 0.75 h / -78 - 0 °C / Inert atmosphere

1.2: 3.5 h / -78 °C / Inert atmosphere

1.3: 0 °C / Saturated solution

2.1: pyridine; dmap / dichloromethane / 0 °C / Inert atmosphere

With pyridine; dmap; lithium diisopropyl amide; In tetrahydrofuran; hexanes; dichloromethane;
DOI:10.1021/ja2109097

Reference yield:

: 774242-01-2
N-[(2Z)-4-hydroxybut-2-en-1-yl]-4-methyl-N-prop-2-yn-1-ylbenzenesulfonamide

: 1365555-08-3
(E)-ethyl 7-(N-(prop-2-ynyl)-N-tosylamino)-4-(pivaloyloxy)hept-5-en-2-ynoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridinium chlorochromate / dichloromethane / 1.5 h / 20 °C / Molecular sieve; Inert atmosphere

2.1: lithium diisopropyl amide / tetrahydrofuran; hexanes / 0.75 h / -78 - 0 °C / Inert atmosphere

2.2: 3.5 h / -78 °C / Inert atmosphere

2.3: 0 °C / Saturated solution

3.1: pyridine; dmap / dichloromethane / 0 °C / Inert atmosphere

With pyridine; dmap; pyridinium chlorochromate; lithium diisopropyl amide; In tetrahydrofuran; hexanes; dichloromethane;
DOI:10.1021/ja2109097