methyl 18-((4-iodophenyl)sulfonyl)-16-methylidene-2-oxo-12-oxa-3,18-diazatricyclo[18.3.1.0^6,11]tetraeicosa-1⁽²⁴⁾,6,8,10,14,20,22-heptaene-4-carboxylate

Base Information

• Chemical Name: methyl 18-((4-iodophenyl)sulfonyl)-16-methylidene-2-oxo-12-oxa-3,18-diazatricyclo[18.3.1.0^6,11]tetraeicosa-1⁽²⁴⁾,6,8,10,14,20,22-heptaene-4-carboxylate
• CAS No.: 669062-08-2
• Molecular Formula: C₃₀H₂₉IN₂O₆S
• Molecular Weight: 672.541

Synonyms:methyl 18-((4-iodophenyl)sulfonyl)-16-methylidene-2-oxo-12-oxa-3,18-diazatricyclo[18.3.1.0^6,11]tetraeicosa-1⁽²⁴⁾,6,8,10,14,20,22-heptaene-4-carboxylate

Chemical Property of methyl 18-((4-iodophenyl)sulfonyl)-16-methylidene-2-oxo-12-oxa-3,18-diazatricyclo[18.3.1.0^6,11]tetraeicosa-1⁽²⁴⁾,6,8,10,14,20,22-heptaene-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 18-((4-iodophenyl)sulfonyl)-16-methylidene-2-oxo-12-oxa-3,18-diazatricyclo[18.3.1.0^6,11]tetraeicosa-1⁽²⁴⁾,6,8,10,14,20,22-heptaene-4-carboxylate

There total 10 articles about methyl 18-((4-iodophenyl)sulfonyl)-16-methylidene-2-oxo-12-oxa-3,18-diazatricyclo[18.3.1.0^6,11]tetraeicosa-1⁽²⁴⁾,6,8,10,14,20,22-heptaene-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

ethene (74-85-1) + methyl N-(3-(N-(2-propyn-1-yl)(4-iodophenyl)sulfonamidomethyl)benzoyl)(2-(2-propen-1-yloxy)phenyl)alaninate (669062-19-5) → methyl 18-((4-iodophenyl)sulfonyl)-16-methylidene-2-oxo-12-oxa-3,18-diazatricyclo[18.3.1.06,11]tetraeicosa-1(24),6,8,10,14,20,22-heptaene-4-carboxylate (669062-08-2) + 3-(2-allyloxy-phenyl)-2-(3-{[(4-iodo-benzenesulfonyl)-(2-methylene-but-3-enyl)-amino]-methyl}-benzoylamino)-propionic acid methyl ester

Guidance literature:

With tri(cycloxexyl)phosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene][benzylidene]ruthenium(IV) dichloride; at 20 ℃; for 4h;

DOI:10.1021/jo0352629

Reference yield:

3-(Chloromethyl)benzoyl chloride (63024-77-1) → methyl 18-((4-iodophenyl)sulfonyl)-16-methylidene-2-oxo-12-oxa-3,18-diazatricyclo[18.3.1.06,11]tetraeicosa-1(24),6,8,10,14,20,22-heptaene-4-carboxylate (669062-08-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 0.536 g / Et₃N / CH₂Cl₂ / 4 h / 0 °C

2: 87 percent / NaH / dimethylformamide

3: 56 percent / PCy₃Cl₂((Mes)2C₃H₅N₂)Ru(=CHPh) / 4 h / 20 °C

With tri(cycloxexyl)phosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene][benzylidene]ruthenium(IV) dichloride; sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo0352629

Reference yield:

p-Iodobenzenesulfonyl chloride (98-61-3) → methyl 18-((4-iodophenyl)sulfonyl)-16-methylidene-2-oxo-12-oxa-3,18-diazatricyclo[18.3.1.06,11]tetraeicosa-1(24),6,8,10,14,20,22-heptaene-4-carboxylate (669062-08-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 45 percent / Et₃N / CH₂Cl₂ / 20 h / 0 °C

2: 87 percent / NaH / dimethylformamide

3: 56 percent / PCy₃Cl₂((Mes)2C₃H₅N₂)Ru(=CHPh) / 4 h / 20 °C

With tri(cycloxexyl)phosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene][benzylidene]ruthenium(IV) dichloride; sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo0352629

upstream raw materials:

ethene

methyl N-(3-(N-(2-propyn-1-yl)(4-iodophenyl)sulfonamidomethyl)benzoyl)(2-(2-propen-1-yloxy)phenyl)alaninate

3-(Chloromethyl)benzoyl chloride

p-Iodobenzenesulfonyl chloride

Downstream raw materials:

18-((4-iodophenyl)sulfonyl)-16-methylidene-2-oxo-12-oxa-3,18-diazatricyclo[18.3.1.0^6,11]tetraeicosa-1⁽²⁴⁾,6,8,10,14,20,22-heptaene-4-carboxylic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 669062-08-2 methyl 18-((4-iodophenyl)sulfonyl)-16-methylidene-2-oxo-12-oxa-3,18-diazatricyclo[18.3.1.0^6,11]tetraeicosa-1⁽²⁴⁾,6,8,10,14,20,22-heptaene-4-carboxylate

Send

Send

Metric Ton KG G Pound L ML

Send

Send