(8-Benzyloxy-3-biphenyl-2-ylmethyl-2-methyl-indolizin-1-yl)-oxo-acetyl chloride

Base Information

Chemical Name:(8-Benzyloxy-3-biphenyl-2-ylmethyl-2-methyl-indolizin-1-yl)-oxo-acetyl chloride
CAS No.:1027153-50-9
Molecular Formula:C₃₁H₂₄ClNO₃
Molecular Weight:493.989
Hs Code.:

Synonyms:(8-Benzyloxy-3-biphenyl-2-ylmethyl-2-methyl-indolizin-1-yl)-oxo-acetyl chloride

Suppliers and Price of (8-Benzyloxy-3-biphenyl-2-ylmethyl-2-methyl-indolizin-1-yl)-oxo-acetyl chloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (8-Benzyloxy-3-biphenyl-2-ylmethyl-2-methyl-indolizin-1-yl)-oxo-acetyl chloride

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Technology Process of (8-Benzyloxy-3-biphenyl-2-ylmethyl-2-methyl-indolizin-1-yl)-oxo-acetyl chloride

There total 7 articles about (8-Benzyloxy-3-biphenyl-2-ylmethyl-2-methyl-indolizin-1-yl)-oxo-acetyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1121-25-1,55780-69-3
2-methyl-3-pyridinol

: 1027153-50-9
(8-Benzyloxy-3-biphenyl-2-ylmethyl-2-methyl-indolizin-1-yl)-oxo-acetyl chloride

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / KOH, tetrabutylammonium bromide / tetrahydrofuran / 1.5 h / Ambient temperature

2: ethyl acetate / 70 °C

3: 1,8-diazabicyclo<5.4.0>undec-7-ene / benzene / Heating

4: 66.9 percent / benzene / 4 h / Heating

5: NaBH₄, AlCl₃ / tetrahydrofuran / 0.75 h / Heating

6: tetrahydrofuran / 0 °C

With potassium hydroxide; sodium tetrahydroborate; aluminium trichloride; tetrabutylammomium bromide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; ethyl acetate; benzene;
DOI:10.1021/jm960395q

Reference yield:

: 100-39-0
benzyl bromide

: 1027153-50-9
(8-Benzyloxy-3-biphenyl-2-ylmethyl-2-methyl-indolizin-1-yl)-oxo-acetyl chloride

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / KOH, tetrabutylammonium bromide / tetrahydrofuran / 1.5 h / Ambient temperature

2: ethyl acetate / 70 °C

3: 1,8-diazabicyclo<5.4.0>undec-7-ene / benzene / Heating

4: 66.9 percent / benzene / 4 h / Heating

5: NaBH₄, AlCl₃ / tetrahydrofuran / 0.75 h / Heating

6: tetrahydrofuran / 0 °C

With potassium hydroxide; sodium tetrahydroborate; aluminium trichloride; tetrabutylammomium bromide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; ethyl acetate; benzene;
DOI:10.1021/jm960395q

Reference yield:

: 177559-01-2
3-(benzyloxy)-2-methylpyridine

: 1027153-50-9
(8-Benzyloxy-3-biphenyl-2-ylmethyl-2-methyl-indolizin-1-yl)-oxo-acetyl chloride

Guidance literature:: Multi-step reaction with 5 steps

1: ethyl acetate / 70 °C

2: 1,8-diazabicyclo<5.4.0>undec-7-ene / benzene / Heating

3: 66.9 percent / benzene / 4 h / Heating

4: NaBH₄, AlCl₃ / tetrahydrofuran / 0.75 h / Heating

5: tetrahydrofuran / 0 °C

With sodium tetrahydroborate; aluminium trichloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; ethyl acetate; benzene;
DOI:10.1021/jm960395q