KYS₀₅₀₄₈

Base Information

• Chemical Name: KYS₀₅₀₄₈
• CAS No.: 839672-58-1
• Molecular Formula: C₃₉H₄₅N₅O₃
• Molecular Weight: 631.818
• Mol file: 839672-58-1.mol

Synonyms:KYS₀₅₀₄₈

Chemical Property of KYS₀₅₀₄₈

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of KYS₀₅₀₄₈

There total 5 articles about KYS₀₅₀₄₈ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,5-diaminopentane (462-94-2) → KYS05048 (839672-58-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 8 percent / benzene / 1 h / 20 °C

2: 59 percent / acetonitrile / 1 h / 20 °C

3: 99 percent / aq. LiOH / tetrahydrofuran / 2 h / 70 °C

4: 80 percent / HOBt; EDC / tetrahydrofuran; CH₂Cl₂ / 48 h / 20 °C

With lithium hydroxide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; dichloromethane; acetonitrile; benzene;

DOI:10.1016/j.bmcl.2004.10.078

Reference yield:

methyl (2E)-3-(2-aminophenyl)propenoate (88939-75-7) → KYS05048 (839672-58-1)

Guidance literature:

Multi-step reaction with 6 steps

1: 94 percent / Et₃N; C₂Cl₆ / benzene / 3 h / Heating

2: 89 percent / benzene / 3 h / 20 °C

3: 8 percent / benzene / 1 h / 20 °C

4: 59 percent / acetonitrile / 1 h / 20 °C

5: 99 percent / aq. LiOH / tetrahydrofuran / 2 h / 70 °C

6: 80 percent / HOBt; EDC / tetrahydrofuran; CH₂Cl₂ / 48 h / 20 °C

With lithium hydroxide; hexachloroethane; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile; benzene; 2: aza-Wittig reaction;

DOI:10.1016/j.bmcl.2004.10.078

Reference yield:

(2E)-3-{2-[(triphenylphosphoranylidene)amino]phenyl}-propenoic acid methyl ester (138386-58-0) → KYS05048 (839672-58-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 89 percent / benzene / 3 h / 20 °C

2: 8 percent / benzene / 1 h / 20 °C

3: 59 percent / acetonitrile / 1 h / 20 °C

4: 99 percent / aq. LiOH / tetrahydrofuran / 2 h / 70 °C

5: 80 percent / HOBt; EDC / tetrahydrofuran; CH₂Cl₂ / 48 h / 20 °C

With lithium hydroxide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; dichloromethane; acetonitrile; benzene; 1: aza-Wittig reaction;

DOI:10.1016/j.bmcl.2004.10.078

upstream raw materials:

1,5-diaminopentane

methyl (2E)-3-(2-aminophenyl)propenoate

(2E)-3-{2-[(triphenylphosphoranylidene)amino]phenyl}-propenoic acid methyl ester

KYS₀₅₀₄₆