triphenyl(4-pyridyl)methane

Base Information

• Chemical Name: triphenyl(4-pyridyl)methane
• CAS No.: 95957-93-0
• Molecular Formula: C₂₄H₁₉N
• Molecular Weight: 321.422
• Mol file: 95957-93-0.mol

Synonyms:triphenyl(4-pyridyl)methane

Chemical Property of triphenyl(4-pyridyl)methane

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of triphenyl(4-pyridyl)methane

There total 4 articles about triphenyl(4-pyridyl)methane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-benzyl pyridine (2116-65-6) + chlorobenzene (108-90-7) → triphenyl(4-pyridyl)methane (95957-93-0) + diphenyl-4-pyridylmethane (3678-72-6)

Guidance literature:

With cesium hydroxide; tricyclohexylphosphine; di(acetonitrile)dichloropalladium; In toluene; xylene; for 14h; Heating;

DOI:10.1021/ol0708119

Reference yield: 71.0%

picoline (108-89-4) + chlorobenzene (108-90-7) → triphenyl(4-pyridyl)methane (95957-93-0)

Guidance literature:

With potassium tert-butylate; palladium diacetate; catacxium A; In o-xylene; at 130 ℃; for 6h; Glovebox; Inert atmosphere; Sealed tube;

DOI:10.1002/adsc.201701347

Reference yield: 40.0%

pyridine-4-carbonitrile (100-48-1) + C28H19NO4 → triphenyl(4-pyridyl)methane (95957-93-0)

Guidance literature:

pyridine-4-carbonitrile; C₂₈H₁₉NO₄; With bis(pinacol)diborane; zinc(II) chloride; In tert-butyl methyl ether; at 80 ℃; for 24h;

With sodium carbonate; In water; regioselective reaction;

DOI:10.1021/acscatal.9b03798

upstream raw materials:

4-benzyl pyridine

chlorobenzene

picoline

pyridine-4-carbonitrile

Refernces

• 1、 Zhang, Shuguang,Hu, Bowen,Zheng, Zhipeng,Walsh, Patrick J.. "Palladium-Catalyzed Triarylation of sp3 C?H Bonds in Heteroarylmethanes: Synthesis of Triaryl(heteroaryl)methanes". supporting information. p. 1493 - 1498. Retrieved 2018/03/05.