4-Bromo-2-fluoro-N,N-dimethylbenzamide

Base Information

• Chemical Name: 4-Bromo-2-fluoro-N,N-dimethylbenzamide
• CAS No.: 749927-80-8
• Molecular Formula: C9H9 Br F N O
• Molecular Weight: 246.079
• Hs Code.: 2924299090
• Mol file: 749927-80-8.mol

Synonyms:4-Bromo-2-fluoro-N,N-dimethylbenzamide

Chemical Property of 4-Bromo-2-fluoro-N,N-dimethylbenzamide

Chemical Property:

• Vapor Pressure: 0.000205mmHg at 25°C
• Refractive Index: 1.546
• Boiling Point: 327.3°C at 760 mmHg
• Flash Point: 151.7°C
• PSA: 20.31000
• Density: 1.49g/cm³
• LogP: 2.29000

Purity/Quality:

97% ^*data from raw suppliers

4-Bromo-2-fluoro-N,N-dimethylbenzamide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Bromo-2-fluoro-N,N-dimethylbenzamide

There total 6 articles about 4-Bromo-2-fluoro-N,N-dimethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.1%

N,N-dimethylammonium chloride (506-59-2) + 2-fluoro-4-bromobenzoic acid (112704-79-7) → 4-bromo-2-fluoro-N,N-dimethylbenzamide (749927-80-8)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 70 ℃; for 2h;

DOI:10.1021/op100267p

Reference yield: 54.0%

dimethyl amine (124-40-3) → 4-bromo-2-fluoro-N,N-dimethylbenzamide (749927-80-8)

Guidance literature:

2-fluoro-4-bromobenzoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 0.5h;

dimethyl amine; With triethylamine; In dichloromethane; at 20 ℃; for 0.166667h;

With hydrogenchloride; In dichloromethane; water; at 20 ℃;

Reference yield:

dimethyl amine (124-40-3) + 4-bromo-2-fluorobenzoyl chloride (151982-51-3) → 4-bromo-2-fluoro-N,N-dimethylbenzamide (749927-80-8)

Guidance literature:

With caesium carbonate; In tetrahydrofuran;

upstream raw materials:

dimethyl amine

2-fluoro-4-bromobenzoic acid

N,N-dimethylammonium chloride

4-bromo-2-fluorobenzoyl chloride

Downstream raw materials:

4-(N,N-dimethylcarbamoyl)-3-fluorophenylboronic acid

2-fluoro-N,N-dimethyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide

(5S)-2-[4-(dimethylaminocarbonyl)-3-fluorophenyl]-α,α-dimethyl-N-(1,3,4-thiadiazol-2-yl)-5H-[1]benzopyrano[2,3-b]pyridin-5-acetamide

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