2-(4-benzyloxy-phenyl)-3-dimethylamino-propionic acid methyl ester

Base Information

• Chemical Name: 2-(4-benzyloxy-phenyl)-3-dimethylamino-propionic acid methyl ester
• CAS No.: 1261351-55-6
• Molecular Formula: C₁₉H₂₃NO₃
• Molecular Weight: 313.397
• Mol file: 1261351-55-6.mol

Synonyms:2-(4-benzyloxy-phenyl)-3-dimethylamino-propionic acid methyl ester

Chemical Property of 2-(4-benzyloxy-phenyl)-3-dimethylamino-propionic acid methyl ester

Chemical Property:

Purity/Quality:

99% ，98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-benzyloxy-phenyl)-3-dimethylamino-propionic acid methyl ester

There total 3 articles about 2-(4-benzyloxy-phenyl)-3-dimethylamino-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dimethyl amine (124-40-3) + methyl 2-(4'-benzyloxyphenyl)propenoate (111751-72-5) → 2-(4-benzyloxy-phenyl)-3-dimethylamino-propionic acid methyl ester (1261351-55-6)

Guidance literature:

With lithium perchlorate; In toluene; at 5 - 30 ℃; for 2.5h;

Reference yield:

(4-benzyloxy-phenyl)-acetic acid methyl ester (68641-16-7) → 2-(4-benzyloxy-phenyl)-3-dimethylamino-propionic acid methyl ester (1261351-55-6)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / tetrabutylammomium bromide / toluene / 5.6 - 6 h / Reflux

2: lithium perchlorate / toluene / 2.5 h / 5 - 30 °C

With lithium perchlorate; potassium carbonate; tetrabutylammomium bromide; In toluene;

Reference yield:

2-[4-(benzyloxy)benzyl]acetic acid (6547-53-1) → 2-(4-benzyloxy-phenyl)-3-dimethylamino-propionic acid methyl ester (1261351-55-6)

Guidance literature:

Multi-step reaction with 3 steps

1: thionyl chloride / 5 - 6 h / 5 - 20 °C

2: potassium carbonate / tetrabutylammomium bromide / toluene / 5.6 - 6 h / Reflux

3: lithium perchlorate / toluene / 2.5 h / 5 - 30 °C

With thionyl chloride; lithium perchlorate; potassium carbonate; tetrabutylammomium bromide; In toluene;

upstream raw materials:

(4-benzyloxy-phenyl)-acetic acid methyl ester

dimethyl amine

methyl 2-(4'-benzyloxyphenyl)propenoate

2-[4-(benzyloxy)benzyl]acetic acid

Downstream raw materials:

1-[2-(dimethylamino)-1-(4-benzyloxyphenyl)ethyl]cyclohexanol

O-desmethylvenlafaxine