(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-methoxybenzamide hydrochloride

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Chemical Name:(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-methoxybenzamide hydrochloride
CAS No.:1196504-67-2
Molecular Formula:C₂₀H₂₂BrN₅O₂*ClH
Molecular Weight:480.792
Hs Code.:

Synonyms:(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-methoxybenzamide hydrochloride

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Chemical Property of (R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-methoxybenzamide hydrochloride

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Technology Process of (R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-methoxybenzamide hydrochloride

There total 7 articles about (R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-methoxybenzamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1196508-42-5
(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-methoxybenzamide trifluoroacetate

: 1196504-67-2
(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-methoxybenzamide hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; diethyl ether; dichloromethane;

Reference yield:

: 1172067-95-6
5-bromo-4-fluoro-1H-pyrrolo[2,3-b]pyridine

: 1196504-67-2
(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-methoxybenzamide hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: nitric acid / 0.5 h / 0 °C

2.1: hydrogenchloride; tin(ll) chloride / 0 - 20 °C

2.2: pH 7

3.1: triethylamine / dichloromethane / 0.5 h / 20 °C

3.2: 0.17 h

4.1: butan-1-ol / 72 h / 155 °C

5.1: 0.33 h / 20 °C

6.1: hydrogenchloride / methanol; diethyl ether; dichloromethane

With hydrogenchloride; nitric acid; triethylamine; tin(ll) chloride; In methanol; diethyl ether; dichloromethane; butan-1-ol;

Reference yield:

: 640735-25-7
4-fluoro-1-[tris(propan-2-yl)silyl]-1H-pyrrolo[2,3-b]pyridine

: 1196504-67-2
(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-3-methoxybenzamide hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1.1: sec.-butyllithium / tetrahydrofuran; cyclohexane / -78 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.33 h / 20 °C

3.1: nitric acid / 0.5 h / 0 °C

4.1: hydrogenchloride; tin(ll) chloride / 0 - 20 °C

4.2: pH 7

5.1: triethylamine / dichloromethane / 0.5 h / 20 °C

5.2: 0.17 h

6.1: butan-1-ol / 72 h / 155 °C

7.1: 0.33 h / 20 °C

8.1: hydrogenchloride / methanol; diethyl ether; dichloromethane

With hydrogenchloride; tetrabutyl ammonium fluoride; sec.-butyllithium; nitric acid; triethylamine; tin(ll) chloride; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; cyclohexane; butan-1-ol;