(4-(2-(4-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-ylamino)piperidin-1-yl)ethyl)piperazin-1-yl)(1H-indol-2-yl)methanone

Base Information

Chemical Name:(4-(2-(4-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-ylamino)piperidin-1-yl)ethyl)piperazin-1-yl)(1H-indol-2-yl)methanone
CAS No.:1345012-53-4
Molecular Formula:C₃₄H₃₈FN₇O
Molecular Weight:579.72
Hs Code.:

Synonyms:(4-(2-(4-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-ylamino)piperidin-1-yl)ethyl)piperazin-1-yl)(1H-indol-2-yl)methanone

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Chemical Property of (4-(2-(4-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-ylamino)piperidin-1-yl)ethyl)piperazin-1-yl)(1H-indol-2-yl)methanone

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Technology Process of (4-(2-(4-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-ylamino)piperidin-1-yl)ethyl)piperazin-1-yl)(1H-indol-2-yl)methanone

There total 11 articles about (4-(2-(4-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-ylamino)piperidin-1-yl)ethyl)piperazin-1-yl)(1H-indol-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Indole-2-carboxylic acid: 1477-50-5,1228050-17-6
Indole-2-carboxylic acid

: C₂₅H₃₃FN₆

: 1345012-53-4
(4-(2-(4-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-ylamino)piperidin-1-yl)ethyl)piperazin-1-yl)(1H-indol-2-yl)methanone

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In acetonitrile; for 3h;
DOI:10.1016/j.bmcl.2011.09.001

Reference yield:

: 103-76-4
1-(2-hydroxyethyl)piperazine

: 1345012-53-4
(4-(2-(4-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-ylamino)piperidin-1-yl)ethyl)piperazin-1-yl)(1H-indol-2-yl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1: dichloromethane / 1 h / 20 °C

2: iodine; triphenylphosphine / dichloromethane / 20 h

3: potassium carbonate / acetone / Reflux

4: trifluoroacetic acid / dichloromethane / 0.5 h

5: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / acetonitrile / 3 h

With iodine; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; triphenylphosphine; trifluoroacetic acid; In dichloromethane; acetone; acetonitrile;
DOI:10.1016/j.bmcl.2011.09.001

Reference yield:

: 1345012-35-2
tert-butyl 4-(2-iodoethyl)piperazine-1-carboxylate

: 1345012-53-4
(4-(2-(4-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-ylamino)piperidin-1-yl)ethyl)piperazin-1-yl)(1H-indol-2-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetone / Reflux

2: trifluoroacetic acid / dichloromethane / 0.5 h

3: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / acetonitrile / 3 h

With potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; trifluoroacetic acid; In dichloromethane; acetone; acetonitrile;
DOI:10.1016/j.bmcl.2011.09.001