tert-butyl 4-(2-(4-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-ylamino)piperidin-1-yl)ethyl)piperazine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-(2-(4-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-ylamino)piperidin-1-yl)ethyl)piperazine-1-carboxylate
• CAS No.: 1345012-52-3
• Molecular Formula: C₃₀H₄₁FN₆O₂
• Molecular Weight: 536.693

Synonyms:tert-butyl 4-(2-(4-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-ylamino)piperidin-1-yl)ethyl)piperazine-1-carboxylate

Chemical Property of tert-butyl 4-(2-(4-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-ylamino)piperidin-1-yl)ethyl)piperazine-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl 4-(2-(4-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-ylamino)piperidin-1-yl)ethyl)piperazine-1-carboxylate

There total 9 articles about tert-butyl 4-(2-(4-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-ylamino)piperidin-1-yl)ethyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

tert-butyl 4-(2-iodoethyl)piperazine-1-carboxylate (1345012-35-2) + norastemizole (75970-99-9) → tert-butyl 4-(2-(4-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-ylamino)piperidin-1-yl)ethyl)piperazine-1-carboxylate (1345012-52-3)

Guidance literature:

With potassium carbonate; In acetone; Reflux;

DOI:10.1016/j.bmcl.2011.09.001

Reference yield:

1-(2-hydroxyethyl)piperazine (103-76-4) → tert-butyl 4-(2-(4-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-ylamino)piperidin-1-yl)ethyl)piperazine-1-carboxylate (1345012-52-3)

Guidance literature:

Multi-step reaction with 3 steps

1: dichloromethane / 1 h / 20 °C

2: iodine; triphenylphosphine / dichloromethane / 20 h

3: potassium carbonate / acetone / Reflux

With iodine; potassium carbonate; triphenylphosphine; In dichloromethane; acetone;

DOI:10.1016/j.bmcl.2011.09.001

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 4-(2-(4-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-ylamino)piperidin-1-yl)ethyl)piperazine-1-carboxylate (1345012-52-3)

Guidance literature:

Multi-step reaction with 3 steps

1: dichloromethane / 1 h / 20 °C

2: iodine; triphenylphosphine / dichloromethane / 20 h

3: potassium carbonate / acetone / Reflux

With iodine; potassium carbonate; triphenylphosphine; In dichloromethane; acetone;

DOI:10.1016/j.bmcl.2011.09.001

upstream raw materials:

1-(2-hydroxyethyl)piperazine

tert-butyl 4-(2-iodoethyl)piperazine-1-carboxylate

norastemizole

di-tert-butyl dicarbonate

Downstream raw materials:

(4-(2-(4-(1-(4-fluorobenzyl)-1H-benzo[d]imidazol-2-ylamino)piperidin-1-yl)ethyl)piperazin-1-yl)(1H-indol-2-yl)methanone

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