N-{2-(butylamino)-1-[5-chloro-2-(1H-pyrrol-1-yl)phenyl]-2-oxoethyl}-N-(4-methoxybenzyl)-3-phenylpropiolamide

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Chemical Name:N-{2-(butylamino)-1-[5-chloro-2-(1H-pyrrol-1-yl)phenyl]-2-oxoethyl}-N-(4-methoxybenzyl)-3-phenylpropiolamide
CAS No.:1604835-54-2
Molecular Formula:C₃₃H₃₂ClN₃O₃
Molecular Weight:554.088
Hs Code.:

Synonyms:N-{2-(butylamino)-1-[5-chloro-2-(1H-pyrrol-1-yl)phenyl]-2-oxoethyl}-N-(4-methoxybenzyl)-3-phenylpropiolamide

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Chemical Property of N-{2-(butylamino)-1-[5-chloro-2-(1H-pyrrol-1-yl)phenyl]-2-oxoethyl}-N-(4-methoxybenzyl)-3-phenylpropiolamide

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Technology Process of N-{2-(butylamino)-1-[5-chloro-2-(1H-pyrrol-1-yl)phenyl]-2-oxoethyl}-N-(4-methoxybenzyl)-3-phenylpropiolamide

There total 4 articles about N-{2-(butylamino)-1-[5-chloro-2-(1H-pyrrol-1-yl)phenyl]-2-oxoethyl}-N-(4-methoxybenzyl)-3-phenylpropiolamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 885056-97-3
5-chloro-2-(1H-pyrrol-1-yl)benzaldehyde

: 2769-64-4
n-butyl isonitrile

: 2393-23-9
4-methoxy-benzylamine

: 637-44-5
phenylpropyolic acid

: 1604835-54-2
N-{2-(butylamino)-1-[5-chloro-2-(1H-pyrrol-1-yl)phenyl]-2-oxoethyl}-N-(4-methoxybenzyl)-3-phenylpropiolamide

Guidance literature:: With sodium sulfate; In methanol; at 20 ℃; for 48h;
DOI:10.1002/ejoc.201301507

Reference yield:

: 885056-96-2
5-chloro-2-(pyrrol-1-yl)benzyl alcohol

: 1604835-54-2
N-{2-(butylamino)-1-[5-chloro-2-(1H-pyrrol-1-yl)phenyl]-2-oxoethyl}-N-(4-methoxybenzyl)-3-phenylpropiolamide

Guidance literature:: Multi-step reaction with 2 steps

1: silica gel; pyridinium chlorochromate / dichloromethane / 3 h / 20 °C

2: sodium sulfate / methanol / 48 h / 20 °C

With silica gel; sodium sulfate; pyridinium chlorochromate; In methanol; dichloromethane; 2: |Ugi Condensation;
DOI:10.1002/ejoc.201301507

Reference yield:

: 88442-97-1
methyl 4-chloro-2-(1H-pyrrol-1-yl)benzoate

: 1604835-54-2
N-{2-(butylamino)-1-[5-chloro-2-(1H-pyrrol-1-yl)phenyl]-2-oxoethyl}-N-(4-methoxybenzyl)-3-phenylpropiolamide

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / diethyl ether / 0.5 h / 0 °C

2: silica gel; pyridinium chlorochromate / dichloromethane / 3 h / 20 °C

3: sodium sulfate / methanol / 48 h / 20 °C

With lithium aluminium tetrahydride; silica gel; sodium sulfate; pyridinium chlorochromate; In methanol; diethyl ether; dichloromethane; 3: |Ugi Condensation;
DOI:10.1002/ejoc.201301507